| Protective immunity against the gastrointestinal nematode Nippostrongylus brasiliensis requires a broad T-cell receptor repertoire. | |
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MedLine Citation:
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PMID: 21896015 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The parasitic gastrointestinal nematode Nippostrongylus brasiliensis induces massive expansion of T helper type 2 (Th2) cells in the lung and small intestine. Th2 cells are a major source of interleukin-4 and interleukin-13, two cytokines that appear essential for rapid worm expulsion. It is unclear whether all Th2 cells induced during infection are pathogen-specific because Th2 cells might also be induced by parasite-derived superantigens or cytokine-mediated bystander activation. Bystander Th2 polarization could explain the largely unspecific B-cell response during primary infection. Furthermore, it is not known whether protective immunity depends on a polyclonal repertoire of T-cell receptor (TCR) specificities. To address these unresolved issues, we performed adoptive transfer experiments and analysed the TCR-Vβ repertoire before and after infection of mice with the helminth N. brasiliensis. The results demonstrate that all Th2 cells were generated by antigen-specific rather than superantigen-driven or cytokine-driven activation. Furthermore, we show that worm expulsion was impaired in mice with a limited repertoire of TCR specificities, indicating that a polyclonal T-cell response is required for protective immunity. |
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Authors:
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Alexander Seidl; Marc Panzer; David Voehringer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunology Volume: 134 ISSN: 1365-2567 ISO Abbreviation: Immunology Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374672 Medline TA: Immunology Country: England |
Other Details:
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Languages: eng Pagination: 214-23 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Immunology © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Institute for Immunology, Ludwig-Maximilians-University, Munich Department of Infection Biology, Institute for Microbiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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