Document Detail


Protective immunity against clinical toxoplasmosis in dairy goats vaccinated with Hammondia hammondi and Hammondia heydorni.
MedLine Citation:
PMID:  7340577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the virulence of Toxoplasma gondii, twelve 2- to 3-month-old goats were inoculated orally with 1,000 to 100,000 infective oocysts of the GT-1 strain of T gondii. Four of 4 goats inoculated with 100,000 oocysts, 4 of 4 goats inoculated with 10,000 oocysts, and 2 of 4 inoculated with 1,000 oocysts died (or became moribund) of acute toxoplasmosis 7 to 26 days after inoculation. Goats vaccinated with Hammondia hammondi or H heydorni were challenge exposed with 10,000 or 100,000 oocysts (10 or 100 median lethal doses). Four of 4 goats vaccinated with H hammondi survived after challenge exposure with 10,000 T gondii oocysts, whereas only 2 of 4 goats survived challenge exposure with 100,000 T gondii oocysts. Of 4 goats vaccinated with H heydorni, 3 died or were euthanatized 13, 14, and 26 days after challenge exposure with 10,000 T gondii oocysts. Goats vaccinated with H hammondi developed low levels of Sabin-Feldman dye test antibodies (less than or equal to 1:64) to T gondii antigen, whereas H heydorni-vaccinated goats generally remained seronegative. The results indicate that goats may be a model to investigate immune protection after vaccination with H hammondi against clinical toxoplasmosis in animals.
Authors:
J P Dubey
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of veterinary research     Volume:  42     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-06-21     Completed Date:  1982-06-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2068-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / analysis*
Coccidia / immunology*
Cross Reactions
Female
Goats / immunology*
Male
Species Specificity
Toxoplasma / immunology*
Toxoplasmosis, Animal / prevention & control*
Vaccination / veterinary
Vaccines / immunology*
Grant Support
ID/Acronym/Agency:
RR-09135/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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