| Protective environment for marrow transplant recipients: a prospective study. | |
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MedLine Citation:
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PMID: 31123 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Laminar air flow isolation and decontamination procedures were evaluated in a prospective randomized study in patients with aplastic anemia or acute leukemia undergoing marrow transplantation from HLA-matched siblings. Patients transplanted in the laminar air flow group had significantly less septicemia and major local infections than did patients in the control group. Nineteen of 46 laminar air flow patients and six of 44 control patients are alive at present. In patients with aplastic anemia the survival was 13 of 17 in the laminar air flow group compared with four of 17 in the control group. In patients with acute leukemia the survival was six of 29 in the laminar air flow group versus two of 27 in the control group. These differences were not statistically significant. Death in both the laminar air flow and control groups was predominantly due to interstitial pneumonitis or recurrent leukemia, which were unaffected by isolation and decontamination. |
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Authors:
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C D Buckner; R A Clift; J E Sanders; J D Meyers; G W Counts; V T Farewell; E D Thomas |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Annals of internal medicine Volume: 89 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-01-26 Completed Date: 1979-01-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 893-901 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Anemia, Aplastic / surgery Bacterial Infections / prevention & control Bone Marrow Transplantation* Child Decontamination Environment, Controlled* Female Graft Rejection Graft vs Host Reaction Herpes Simplex / etiology Humans Leukemia / surgery Male Middle Aged Mycoses / prevention & control Postoperative Complications / prevention & control* Prospective Studies Pulmonary Fibrosis / etiology Sepsis / prevention & control Transplantation, Homologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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