Document Detail

Protective environment for marrow transplant recipients: a prospective study.
MedLine Citation:
PMID:  31123     Owner:  NLM     Status:  MEDLINE    
Laminar air flow isolation and decontamination procedures were evaluated in a prospective randomized study in patients with aplastic anemia or acute leukemia undergoing marrow transplantation from HLA-matched siblings. Patients transplanted in the laminar air flow group had significantly less septicemia and major local infections than did patients in the control group. Nineteen of 46 laminar air flow patients and six of 44 control patients are alive at present. In patients with aplastic anemia the survival was 13 of 17 in the laminar air flow group compared with four of 17 in the control group. In patients with acute leukemia the survival was six of 29 in the laminar air flow group versus two of 27 in the control group. These differences were not statistically significant. Death in both the laminar air flow and control groups was predominantly due to interstitial pneumonitis or recurrent leukemia, which were unaffected by isolation and decontamination.
C D Buckner; R A Clift; J E Sanders; J D Meyers; G W Counts; V T Farewell; E D Thomas
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of internal medicine     Volume:  89     ISSN:  0003-4819     ISO Abbreviation:  Ann. Intern. Med.     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-01-26     Completed Date:  1979-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372351     Medline TA:  Ann Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  893-901     Citation Subset:  AIM; IM    
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MeSH Terms
Acute Disease
Anemia, Aplastic / surgery
Bacterial Infections / prevention & control
Bone Marrow Transplantation*
Environment, Controlled*
Graft Rejection
Graft vs Host Reaction
Herpes Simplex / etiology
Leukemia / surgery
Middle Aged
Mycoses / prevention & control
Postoperative Complications / prevention & control*
Prospective Studies
Pulmonary Fibrosis / etiology
Sepsis / prevention & control
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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