| Protective effects of vitamin E and selenium against dimethoate-induced cardiotoxicity in vivo: Biochemical and histological studies. | |
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MedLine Citation:
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PMID: 21887815 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is considerable interest in the study of free radical-mediated damage to biological systems due to pesticide exposure. However, there is a lack of consensus as to which determinations are best used to quantify future risks arising from xenobiotic exposure and natural antioxidant interventions. Our study investigated the potential ability of selenium and/or vitamin E, used as nutritional supplements, to alleviate cardiotoxicity induced by dimethoate. Female Wistar rats were exposed for 30 days either to dimethoate (0.2 g L(-1) of drinking water), dimethoate+selenium (0.5 mg kg(-1) of diet), dimethoate+vitamin E (100 mg kg(-1) of diet), or dimethoate+selenium+vitamin E. The exposure of rats to dimethoate promoted oxidative stress with a rise in malondialdehyde, advanced protein oxidation, and protein carbonyl levels. An increase of glutathione peroxidase, superoxide dismutase, and catalase activities was also noted. A fall in acetylcholinesterase and Na(+) K(+) -ATPase activities, glutathione, nonprotein thiols, vitamins C and E levels was observed. Plasma levels of cholesterol, triglycerides, and low density lipoprotein-cholesterol increased and those of high density lipoprotein-cholesterol decreased. Coadministration of selenium or vitamin E to the diet of dimethoate-treated rats ameliorated the biochemical parameters cited above. The histopathological findings confirmed the biochemical results and the potential protective effects of selenium and vitamin E against cardiotoxicity induced by dimethoate. © 2011 Wiley Periodicals, Inc. Environ Toxicol, 2011. |
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Authors:
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Ibtissem Ben Amara; Nejla Soudani; Ahmed Hakim; Afef Troudi; Khaled Mounir Zeghal; Tahia Boudawara; Najiba Zeghal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-2 |
Journal Detail:
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Title: Environmental toxicology Volume: - ISSN: 1522-7278 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100885357 Medline TA: Environ Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Animal Physiology Laboratory, Sfax Faculty of Science, BP1171, 3000 Sfax, University of Sfax, Tunisia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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