| Protective effects of vitamin E against 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos. | |
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MedLine Citation:
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PMID: 18973944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3,3',4,4',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100nM PCB126 and compared with a second group that was co-exposed with 100muM vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists. |
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Authors:
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Yi-Rang Na; Seung-Hyeok Seok; Min-Won Baek; Hui-Young Lee; Dong-Jae Kim; Sung-Hoon Park; Hyun-Kyoung Lee; Jae-Hak Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-29 |
Journal Detail:
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Title: Ecotoxicology and environmental safety Volume: 72 ISSN: 1090-2414 ISO Abbreviation: Ecotoxicol. Environ. Saf. Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-02-09 Completed Date: 2009-05-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805381 Medline TA: Ecotoxicol Environ Saf Country: United States |
Other Details:
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Languages: eng Pagination: 714-9 Citation Subset: IM |
Affiliation:
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Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Priority Research Institute, Seoul National University, Seoul 151-742, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Drug Antagonism Edema / chemically induced, pathology Embryo, Nonmammalian / drug effects*, metabolism, physiopathology Embryonic Development / drug effects Estrogen Antagonists / toxicity* Gene Expression / drug effects Oxidative Stress / drug effects Pericardium / drug effects, pathology Polychlorinated Biphenyls / toxicity* RNA, Messenger / metabolism Vitamin E / pharmacology* Water Pollutants, Chemical / toxicity* Yolk Sac / drug effects, pathology Zebrafish* Zebrafish Proteins / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Estrogen Antagonists; 0/Polychlorinated Biphenyls; 0/RNA, Messenger; 0/Water Pollutants, Chemical; 0/Zebrafish Proteins; 1406-18-4/Vitamin E; 57465-28-8/3,4,5,3',4'-pentachlorobiphenyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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