Document Detail

Protective effects of vitamin E against 3,3',4,4',5-pentachlorobiphenyl (PCB126) induced toxicity in zebrafish embryos.
MedLine Citation:
PMID:  18973944     Owner:  NLM     Status:  MEDLINE    
3,3',4,4',5-Pentachlorinated biphenyls 126 (PCB126) is a global environmental contaminant that can induce cellular oxidative stress. We investigated whether vitamin E can protect against toxicity from PCB126 during zebrafish (Danio rerio) development. Zebrafish embryos were exposed to 100nM PCB126 and compared with a second group that was co-exposed with 100muM vitamin E until 5 days post fertilization. PCB126 induced pericardial sac edema, yolk sac edema, and growth retardation in zebrafish embyos. In contrast, vitamin E co-exposure group did not show any gross changes. Real-time PCR results showed that vitamin E co-exposure group were restored to control group for the expression levels of heat shock protein 70 Cognate, aryl hydrocarbon receptor type-2, cytochrome P450 1A, and superoxide dismutase-1. These data give insights into the use of vitamin E to reduce PCB126-mediated toxicity and into the use of zebrafish embryos for exploring mechanisms underlying the oxidative potential of AHR agonists.
Yi-Rang Na; Seung-Hyeok Seok; Min-Won Baek; Hui-Young Lee; Dong-Jae Kim; Sung-Hoon Park; Hyun-Kyoung Lee; Jae-Hak Park
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-29
Journal Detail:
Title:  Ecotoxicology and environmental safety     Volume:  72     ISSN:  1090-2414     ISO Abbreviation:  Ecotoxicol. Environ. Saf.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7805381     Medline TA:  Ecotoxicol Environ Saf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  714-9     Citation Subset:  IM    
Department of Laboratory Animal Medicine, College of Veterinary Medicine and KRF Zoonotic Disease Priority Research Institute, Seoul National University, Seoul 151-742, Republic of Korea.
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MeSH Terms
Antioxidants / pharmacology*
Drug Antagonism
Edema / chemically induced,  pathology
Embryo, Nonmammalian / drug effects*,  metabolism,  physiopathology
Embryonic Development / drug effects
Estrogen Antagonists / toxicity*
Gene Expression / drug effects
Oxidative Stress / drug effects
Pericardium / drug effects,  pathology
Polychlorinated Biphenyls / toxicity*
RNA, Messenger / metabolism
Vitamin E / pharmacology*
Water Pollutants, Chemical / toxicity*
Yolk Sac / drug effects,  pathology
Zebrafish Proteins / genetics,  metabolism
Reg. No./Substance:
0/Antioxidants; 0/Estrogen Antagonists; 0/Polychlorinated Biphenyls; 0/RNA, Messenger; 0/Water Pollutants, Chemical; 0/Zebrafish Proteins; 1406-18-4/Vitamin E; 57465-28-8/3,4,5,3',4'-pentachlorobiphenyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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