Document Detail


Protective effects of ursodeoxycholic acid on chenodeoxycholic acid-induced liver injury in hamsters.
MedLine Citation:
PMID:  17854144     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate the effects of ursodeoxycholic acid (UDCA) on chenodeoxycholic acid (CDCA)-induced liver injury in hamsters, and to elucidate a correlation between liver injury and bile acid profiles in the liver. METHODS: Liver injury was induced in hamsters by administration of 0.5% (w/w) CDCA in their feed for 7 d. UDCA (50 mg/kg and 150 mg/kg) was administered for the last 3 d of the experiment. RESULTS: At the end of the experiment, serum alanine aminotransferase (ALT) increased more than 10 times and the presence of liver injury was confirmed histologically. Marked increase in bile acids was observed in the liver. The amount of total bile acids increased approximately three-fold and was accompanied by the increase in hydrophobic bile acids, CDCA and lithocholic acid (LCA). UDCA (50 mg/kg and 150 mg/kg) improved liver histology, with a significant decrease (679.3 +/- 77.5 U/L vs 333.6 +/- 50.4 U/L and 254.3 +/- 35.5 U/L, respectively, P < 0.01) in serum ALT level. UDCA decreased the concentrations of the hydrophobic bile acids, and as a result, a decrease in the total bile acid level in the liver was achieved. CONCLUSION: The results show that UDCA improves oral CDCA-induced liver damage in hamsters. The protective effects of UDCA appear to result from a decrease in the concentration of hydrophobic bile acids, CDCA and LCA, which accumulate and show the cytotoxicity in the liver.
Authors:
Tomomichi Iwaki; Kaoru Ishizaki; Shuji Kinoshita; Hideki Tanaka; Atsushi Fukunari; Makoto Tsurufuji; Teruaki Imada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-14     Completed Date:  2007-11-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5003-8     Citation Subset:  IM    
Affiliation:
Research Laboratory III (Immunology), Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, 1000 Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan. iwaki.tomomichi@mh.m-pharma.co.jp
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Animals
Bile Acids and Salts / metabolism
Body Weight / drug effects
Chenodeoxycholic Acid
Cholagogues and Choleretics / pharmacology*
Cricetinae
Drug-Induced Liver Injury
Eating / drug effects
Liver / metabolism,  pathology
Liver Diseases / pathology,  prevention & control*
Mesocricetus
Ursodeoxycholic Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholagogues and Choleretics; 128-13-2/Ursodeoxycholic Acid; 474-25-9/Chenodeoxycholic Acid; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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