Document Detail


Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin.
MedLine Citation:
PMID:  19146606     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ultraviolet (UV) irradiation of the skin leads to acute inflammatory reactions, such as erythema, sunburn, and chronic reactions, including premature skin aging and skin cancer. AIM: In this study, the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage. SUBJECTS/METHODS: Ten subjects (age, 18-60 years; Fitzpatrick skin types II and III) were randomized and treated with antioxidant product or vehicle control on the lower back for four consecutive days. On day 3, the minimal erythema dose (MED) was determined for each subject at a different site on the back. On day 4, the two test sites received solar-simulated UV irradiation 1-5x MED at 1x MED intervals. On day 5, digital images were taken, and 4-mm punch biopsies were collected from the two 5x MED test sites and a control site from each subject for morphology and immunohistochemical studies. RESULTS: UV irradiation significantly increased the erythema of human skin in a linear manner from 1x to 5x MED. As early as 24 h after exposure to 5x MEDs of UV irradiation, there were significant increases in sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, and p53 protein expression. All these changes were attenuated by the antioxidant composition. UV irradiation also suppressed the amount of CD1a-expressing Langerhans cells, indicating immunosuppressive effects of a single 5x MED dose of UV irradiation. Pretreatment of skin with the antioxidant composition blocked this effect. CONCLUSION: This study confirms the protective role of a unique mixture of antioxidants containing vitamin C, ferulic acid, and phloretin on human skin from the harmful effects of UV irradiation. Phloretin, in addition to being a potent antioxidant, may stabilize and increase the skin availability of topically applied vitamin C and ferulic acid. We propose that antioxidant mixture will complement and synergize with sunscreens in providing photoprotection for human skin.
Authors:
Christian Oresajo; Thomas Stephens; Peter D Hino; Robert M Law; Margarita Yatskayer; Peter Foltis; Sreekumar Pillai; Sheldon R Pinnell
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cosmetic dermatology     Volume:  7     ISSN:  1473-2165     ISO Abbreviation:  J Cosmet Dermatol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101130964     Medline TA:  J Cosmet Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  290-7     Citation Subset:  IM    
Affiliation:
L'Oreal USA, Clark, NJ 07066, USA. coresajo@rd.us.loreal.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Cutaneous
Adolescent
Adult
Antioxidants / administration & dosage,  pharmacology*
Ascorbic Acid / administration & dosage,  pharmacology*
Coumaric Acids / administration & dosage,  pharmacology*
Drug Combinations
Erythema / drug therapy*,  etiology,  prevention & control
Female
Humans
Male
Middle Aged
Phloretin / administration & dosage,  pharmacology*
Skin / drug effects*,  radiation effects
Skin Aging / drug effects*,  radiation effects
Treatment Outcome
Ultraviolet Rays / adverse effects*
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Coumaric Acids; 0/Drug Combinations; 1135-24-6/ferulic acid; 50-81-7/Ascorbic Acid; 60-82-2/Phloretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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