| Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin. | |
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MedLine Citation:
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PMID: 19146606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ultraviolet (UV) irradiation of the skin leads to acute inflammatory reactions, such as erythema, sunburn, and chronic reactions, including premature skin aging and skin cancer. AIM: In this study, the effects of a topical antioxidant mixture consisting of vitamin C, ferulic acid, and phloretin on attenuating the harmful effects of UV irradiation on normal healthy volunteers were studied using biomarkers of skin damage. SUBJECTS/METHODS: Ten subjects (age, 18-60 years; Fitzpatrick skin types II and III) were randomized and treated with antioxidant product or vehicle control on the lower back for four consecutive days. On day 3, the minimal erythema dose (MED) was determined for each subject at a different site on the back. On day 4, the two test sites received solar-simulated UV irradiation 1-5x MED at 1x MED intervals. On day 5, digital images were taken, and 4-mm punch biopsies were collected from the two 5x MED test sites and a control site from each subject for morphology and immunohistochemical studies. RESULTS: UV irradiation significantly increased the erythema of human skin in a linear manner from 1x to 5x MED. As early as 24 h after exposure to 5x MEDs of UV irradiation, there were significant increases in sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, and p53 protein expression. All these changes were attenuated by the antioxidant composition. UV irradiation also suppressed the amount of CD1a-expressing Langerhans cells, indicating immunosuppressive effects of a single 5x MED dose of UV irradiation. Pretreatment of skin with the antioxidant composition blocked this effect. CONCLUSION: This study confirms the protective role of a unique mixture of antioxidants containing vitamin C, ferulic acid, and phloretin on human skin from the harmful effects of UV irradiation. Phloretin, in addition to being a potent antioxidant, may stabilize and increase the skin availability of topically applied vitamin C and ferulic acid. We propose that antioxidant mixture will complement and synergize with sunscreens in providing photoprotection for human skin. |
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Authors:
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Christian Oresajo; Thomas Stephens; Peter D Hino; Robert M Law; Margarita Yatskayer; Peter Foltis; Sreekumar Pillai; Sheldon R Pinnell |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cosmetic dermatology Volume: 7 ISSN: 1473-2165 ISO Abbreviation: J Cosmet Dermatol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2009-01-16 Completed Date: 2009-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101130964 Medline TA: J Cosmet Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 290-7 Citation Subset: IM |
Affiliation:
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L'Oreal USA, Clark, NJ 07066, USA. coresajo@rd.us.loreal.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Adolescent Adult Antioxidants / administration & dosage, pharmacology* Ascorbic Acid / administration & dosage, pharmacology* Coumaric Acids / administration & dosage, pharmacology* Drug Combinations Erythema / drug therapy*, etiology, prevention & control Female Humans Male Middle Aged Phloretin / administration & dosage, pharmacology* Skin / drug effects*, radiation effects Skin Aging / drug effects*, radiation effects Treatment Outcome Ultraviolet Rays / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Coumaric Acids; 0/Drug Combinations; 1135-24-6/ferulic acid; 50-81-7/Ascorbic Acid; 60-82-2/Phloretin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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