| Protective effects of therapeutic cold and heat against the oxidative damage induced by a muscle strain injury in rats. | |
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MedLine Citation:
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PMID: 20544483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanisms of action of physical agents commonly used to treat skeletal muscle lesions are not well understood. In this study, we examined whether the modulation of oxidative stress is involved in the beneficial effects of cold and heat on gastrocnemius muscle strain injury. Adult male Wistar rats were submitted to a strain injury and treated with therapeutic agents in an isolated or combined form. Strain damage caused an increase in muscle and blood oxidative damage. We suggest that this oxidative damage might be related to the impairment of the muscle cell structure, since we observed a significant positive correlation between increased plasma creatine kinase activity and both oxidized dichlorofluoresceine and lipid peroxidation levels in muscle and blood. The intensity of the inflammatory response appears also to be an important factor in the genesis of oxidative damage immediately following a muscle strain injury. Therapeutic cold seems to be more effective in preventing the damage induced by a strain injury, possibly due to its capacity to control the impairment of muscle cell structure and to modulate the intensity of the inflammatory response that follows a muscle strain injury. |
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Authors:
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Nélson Carvalho; Gustavo Puntel; Philipe Correa; Priscila Gubert; Guilherme Amaral; Jefferson Morais; Luiz Royes; João da Rocha; Félix Soares |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of sports sciences Volume: 28 ISSN: 1466-447X ISO Abbreviation: J Sports Sci Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-06 Completed Date: 2011-05-11 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 8405364 Medline TA: J Sports Sci Country: England |
Other Details:
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Languages: eng Pagination: 923-35 Citation Subset: IM |
Affiliation:
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Departamento de Química, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood / metabolism Creatine Kinase / blood Cryotherapy* Fluoresceins / metabolism Hot Temperature / therapeutic use* Inflammation / etiology, metabolism, therapy* Lipid Peroxidation Male Muscle, Skeletal / metabolism* Muscular Diseases / complications, metabolism, therapy* Oxidative Stress* Rats Rats, Wistar Sprains and Strains / complications, metabolism, therapy* |
| Chemical | |
Reg. No./Substance:
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0/Fluoresceins; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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