Document Detail

Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents.
MedLine Citation:
PMID:  8215239     Owner:  NLM     Status:  MEDLINE    
The effects of sesamin, a potent inhibitor of delta 5-desaturase in polyunsaturated fatty acid biosynthesis, on the fatty acid compositions of tissue lipids and liver functions were examined in rodents. When a mixture of sesamin and episesamin (51.1:48.2, w/w) was given to rats at a dietary level of 0.5% for 13 days, the proportions of dihomo-gamma-linolenic acid significantly increased not only in the liver but also in plasma and hemocytes, suggesting an interference with delta 5-desaturation by these lignans. The sesamin preparation at the dietary level of 1% improved changes in various blood parameters of the mouse, such as aspartate aminotransferase and alanine aminotransferase activities, and the concentrations of total cholesterol, triglyceride and total bilirubin, caused by continuous inhalation of ethanol. In addition, sesamin showed a significant protective effect against the accumulation of fat droplets and vacuolar degeneration in the mouse liver, as confirmed on histological examination. Sesamin, at the level of 100 mg/kg body weight, also tended to prevent liver lipid accumulation by carbon tetrachloride in mice. These results indicate that sesamin and a related lignan compound have an ability to improve liver function.
K Akimoto; Y Kitagawa; T Akamatsu; N Hirose; M Sugano; S Shimizu; H Yamada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  37     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1993  
Date Detail:
Created Date:  1993-10-28     Completed Date:  1993-10-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  218-24     Citation Subset:  IM    
Institute for Biomedical Research, Suntory Ltd., Osaka, Japan.
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MeSH Terms
Administration, Inhalation
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Carbon Tetrachloride / toxicity*
Dioxoles / pharmacology,  therapeutic use*
Drug-Induced Liver Injury*
Ethanol / administration & dosage,  toxicity*
Fatty Acid Desaturases / metabolism
Fatty Acids / metabolism
Lipid Metabolism
Liver Diseases / prevention & control*
Microsomes, Liver / drug effects,  metabolism
Rats, Wistar
Reg. No./Substance:
0/Dioxoles; 0/Fatty Acids; 0/Lignans; 56-23-5/Carbon Tetrachloride; 607-80-7/sesamin; 64-17-5/Ethanol; EC 1.14.19.-/Fatty Acid Desaturases; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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