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Protective effects of salvianolate on microvascular flow in a porcine model of myocardial ischaemia and reperfusion.
MedLine Citation:
PMID:  21693368     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Microvascular reflow is crucial for myocyte survival during ischaemia/reperfusion injury.
AIMS: We aimed to assess if salvianolate, a highly purified aqueous extract from Radix salviae miltiorrhizae, could improve impaired microvascular reflow induced by ischaemia/reperfusion injury, using a porcine closed-chest model.
METHODS: Left anterior descending coronary artery ligation was created by balloon occlusion for 2h followed by reperfusion for 14 days. Salvianolate was administrated intravenously for 7 days at low dose (5mg/kg/day), high dose (10mg/kg/day) or high dose combined with one 20mg intracoronary bolus injection just at the beginning of reperfusion. Control-group animals were only given the same volume of saline.
RESULTS: After 14 days of reperfusion, animals treated with high-dose salvianolate showed improved myocardial perfusion assessed by real-time myocardial contrast echocardiography and coloured microspheres. The beneficial effect was further supported by increased capillary density and decreased infarct size. All these effects eventually resulted in well-preserved cardiac function detected by echocardiography. Moreover, we also demonstrated that salvianolate administration was associated with elevated superoxide dismutase activity, thioredoxin activity and glutathione concentration, and reduced malondialdehyde concentration, which, in turn, resulted in a significant decrease in terminal deoxynucleotide transferase-mediated dUTP nick end labelling-positive cells and an increased ratio of Bcl-2 to Bax expression.
CONCLUSION: Intravenous salvianolate at a dose of 10mg/kg/day for 7 days had significant beneficial effects on myocardial microvascular reflow, which were associated with decreased oxidative stress and apoptosis.
Beibei Han; Xin Zhang; Qingyong Zhang; Gang Zhao; Junbo Wei; Shixin Ma; Wei Zhu; Meng Wei
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Publication Detail:
Type:  Journal Article     Date:  2011-06-08
Journal Detail:
Title:  Archives of cardiovascular diseases     Volume:  104     ISSN:  1875-2128     ISO Abbreviation:  Arch Cardiovasc Dis     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-06-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465655     Medline TA:  Arch Cardiovasc Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  313-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Masson SAS. All rights reserved.
Division of Cardiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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