Document Detail

Protective effects of a red orange extract on UVB-induced damage in human keratinocytes.
MedLine Citation:
PMID:  18356584     Owner:  NLM     Status:  MEDLINE    
UV light is considered one of the major etiological factor in skin aging, cancer and also to systemic impairment such as immunosuppression. Increased production of reactive oxygen species (ROS) and oxidative stress condition are known to play a central role in initiating and driving the signalling events that lead to cellular response following UV irradiation. In the present study we have investigated the photoprotective activity of a standardized extract from red orange (ROE), obtained from three red orange varieties and containing as main active principles phenolic compounds (anthocyanins, flavanones and hydroxycinnamic acids) and ascorbic acid. The aim of this study was to evaluate the efficacy of ROE in modulating cellular responses to UVB in human keratinocytes (HaCaT). Our data indicate that ROE is potentially able to efficiently counteract UVB-induced response, and in particular some events associated to inflammation and apoptosis, such as NF-kB and AP-1 translocation and procaspase-3 cleavage. This activity is probably due to a block of cellular oxidative stress-related events. Thus we can propose ROE as a useful natural standardised extract in skin photoprotection with promising applications in the field of dermatology.
Francesco Cimino; Mariateresa Cristani; Antonina Saija; Franco Paolo Bonina; Fabio Virgili
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BioFactors (Oxford, England)     Volume:  30     ISSN:  0951-6433     ISO Abbreviation:  Biofactors     Publication Date:  2007  
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807441     Medline TA:  Biofactors     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
Department of Farmaco-Biologico, University of Messina, Messina, Italy.
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MeSH Terms
Anthocyanins / analysis
Apoptosis / drug effects
Ascorbic Acid / analysis
Blotting, Western
Cell Line, Transformed
Citrus sinensis / chemistry*
Coumaric Acids / analysis
Electrophoretic Mobility Shift Assay
Flavanones / analysis
Fruit / chemistry*
Inflammation / prevention & control
Keratinocytes / drug effects*,  radiation effects
Plant Extracts / chemistry,  pharmacology*
Ultraviolet Rays / adverse effects*
Reg. No./Substance:
0/Anthocyanins; 0/Coumaric Acids; 0/Flavanones; 0/Plant Extracts; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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