| Protective effects of ranitidine in ibuprofen gastroduodenopathy. An endoscopic controlled double blind study | |
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MedLine Citation:
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PMID: 7612060 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Protective Effect of Ranitidine in Ibuprofen Gastroduodenopathy/An endoscopically controlled double-blind study in healthy volunteers. In a randomized parallel double-blind study the gastroduodenal effects of 600 mg ibuprofen racemate (CAS 15687-27-1) tid in the presence of 150 mg ranitidine (CAS 66357-35-5, Sostril) bid or placebo was evaluated in 32 healthy volunteers undergoing upper gastrointestinal endoscopy. Drugs were taken during a period of 7 days. Endoscopic controls were performed at entry and repeated after 7 days of treatment. A damaging score was used to asses the lesions. At entry both groups showed comparable mucosal damages. The median values under ibuprofen/placebo were 1 (range 0-1) and under ibuprofen/ranitidine 1 (range 0-2). After 7 days of treatment the median lesions score increased under ibuprofen/placebo to 8 (range 1-20) whereas corresponding values in the ibuprofen/ranitidine group were constant at 1 (range 1-9). The differences between both groups were statistically significant (p < 0.05). Our data underline the protective effect of ranitidine 150 mg bid against ibuprofen both on the stomach as well as on the duodenum. |
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Authors:
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P Müller; E M Koch; B Simon |
Publication Detail:
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Type: Clinical Trial; English Abstract; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Arzneimittel-Forschung Volume: 45 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1995 May |
Date Detail:
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Created Date: 1995-08-14 Completed Date: 1995-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY |
Other Details:
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Languages: ger Pagination: 601-3 Citation Subset: IM |
Affiliation:
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Krankenhaus Salem, Heidelberg. |
Vernacular Title:
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Schutzwirkung von Ranitidin bei Ibuprofen-Gastroduodenopathie. Eine endoskopisch kontrollierte Doppelblindstudie an Probanden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Double-Blind Method Endoscopy, Gastrointestinal Humans Ibuprofen / antagonists & inhibitors*, toxicity Male Peptic Ulcer / chemically induced, prevention & control* Ranitidine / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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15687-27-1/Ibuprofen; 66357-35-5/Ranitidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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