| Protective effects of phenolic compounds on CCl4-induced toxicity in isolated rat hepatocytes. | |
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MedLine Citation:
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PMID: 1590889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The protective effects of a series of phenolic compounds, phenolic acids and flavonoids on the cytotoxicity of CCl4 in rat hepatocytes were studied. A number of flavones, 7,8-dihydroxy-flavone, luteolin and hypolaetin-8-glucoside, flavonols, morin, quercetin, robinetin and gossypin, phenolic acids, gallic, caffeic and chlorogenic acids, as well as the flavane (+)-catechin significantly inhibited alanine amine transferase (ALT) release. Catechol groups are determinant for the protective activity of flavonoids and cinnamic acid derivatives, as well as the resorcinol or pyrogallol moieties in the B ring of flavonoids. In benzoic acid derivatives a pyrogallol group is required. This feature is associated with the inhibition of ALT spontaneous release. |
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Authors:
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M T Añón; A Ubeda; M J Alcaraz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Zeitschrift für Naturforschung. C, Journal of biosciences Volume: 47 ISSN: 0939-5075 ISO Abbreviation: Z. Naturforsch., C, J. Biosci. Publication Date: 1992 Mar-Apr |
Date Detail:
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Created Date: 1992-06-26 Completed Date: 1992-06-26 Revised Date: 2009-11-04 |
Medline Journal Info:
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Nlm Unique ID: 8912155 Medline TA: Z Naturforsch C Country: GERMANY |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Affiliation:
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Departamento de Farmacología, Facultad de Farmacia, Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Tetrachloride / toxicity* Cells, Cultured Flavonoids / pharmacology* Liver / cytology, drug effects* Phenols / pharmacology* Rats Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Flavonoids; 0/Phenols; 56-23-5/Carbon Tetrachloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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