Document Detail

Protective effects of pentoxifylline in retinal ischemia/reperfusion injury.
MedLine Citation:
PMID:  12913323     Owner:  NLM     Status:  MEDLINE    
We studied the effect of pentoxifylline on retinal lipid peroxidation and histopathologic changes due to ischemia/reperfusion (I/R). A total of 15 pigmented male guinea pigs were divided into 3 equal groups as control, sham and treatment groups. After application of high intraocular pressure for 90 min for the induction of retinal ischemia, 24-hour reperfusion was established in the sham and treatment groups. In the treatment and sham groups, either 45 mg/kg of pentoxifylline or saline was given 3 times at 8-hour intervals. Biochemical assay and histopathologic evaluation were performed on one randomly selected eye of each animal which was enucleated at the end of the reperfusion period, and retinal malondialdehyde (MDA) levels and thickness of the retinal tissue were determined for each group. The mean MDA level of the sham group was significantly higher versus the control and treatment groups (p < 0.001). When compared with the control group, the mean MDA level of the treatment group was slightly higher, but the difference was not statistically significant (p > 0.05). In comparison with the control group there was a significant increase in the thickness of the retina in the sham group (p < 0.0001), and no significant difference was found in the retinal thickness of the treatment group (p > 0.05). Pentoxifylline might have a preventive effect on the I/R injury of the retina.
Tamer Demir; Fatih Ulas; Ibrahim Ozercan; Nevin Ilhan; Ulku Celiker; M Akif Yasar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde     Volume:  217     ISSN:  0030-3755     ISO Abbreviation:  Ophthalmologica     Publication Date:    2003 Sep-Oct
Date Detail:
Created Date:  2003-08-12     Completed Date:  2003-11-17     Revised Date:  2007-09-17    
Medline Journal Info:
Nlm Unique ID:  0054655     Medline TA:  Ophthalmologica     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  337-41     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Ophthalmology, Firat University Medical School, Firat Tip Merkezi, TR-23200 Elazig, Turkey.
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MeSH Terms
Free Radical Scavengers / pharmacology*
Guinea Pigs
Ischemia / metabolism,  pathology,  prevention & control*
Lipid Peroxidation / drug effects
Malondialdehyde / metabolism
Pentoxifylline / pharmacology*
Phosphodiesterase Inhibitors / pharmacology*
Reperfusion Injury / metabolism,  pathology,  prevention & control*
Retinal Vessels / drug effects*,  metabolism,  pathology
Reg. No./Substance:
0/Free Radical Scavengers; 0/Phosphodiesterase Inhibitors; 542-78-9/Malondialdehyde; 6493-05-6/Pentoxifylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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