Document Detail


Protective effects of neutral amino acids against amphipathic drug-induced hemolysis.
MedLine Citation:
PMID:  8593474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Some neutral amino acids were compared for their anti-hemolytic effects with sugars which are well-known colloid-osmotic protectants. The kinetic studies in isotonic suspensions of erythrocytes indicated that the hemolysis induced by the amphipathic drug chlorpromazine (CPZ) or flufenamic acid (FA) was retarded by addition of sugars, and the degree of the anti-hemolytic effect increased with increases in molecular size. Phenylalanine (Phe), the largest among the amino acids tested, showed the greatest inhibitory effect on CPZ-induced hemolysis, but not on FA-induced hemolysis. This demonstrated that the anti-hemolytic effects of amino acids were not the result of colloid-osmotic protection. Hemolytic actions of amino acids were also examined to determine their interaction with the erythrocyte membrane, and the mechanism of their inhibitory effects against amphipathic drug-induced hemolysis was discussed.
Authors:
Y Morimoto; Y Yutani; Y Kado; T Iida; M Shiota; Y Takeuchi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  18     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-04-11     Completed Date:  1996-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1535-8     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / pharmacology*
Animals
Carbohydrates / pharmacology
Chlorpromazine / antagonists & inhibitors,  toxicity*
Erythrocytes / drug effects
Flufenamic Acid / antagonists & inhibitors,  toxicity*
Hemolysis / drug effects*
Kinetics
Molecular Weight
Osmolar Concentration
Phospholipids / blood
Rabbits
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Carbohydrates; 0/Phospholipids; 50-53-3/Chlorpromazine; 530-78-9/Flufenamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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