| Protective effects of melatonin in reduction of oxidative damage and immunosuppression induced by aflatoxin B(1) -contaminated diets in young chicks. | |
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MedLine Citation:
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PMID: 19760614 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In the present study, the ability of aflatoxin B(1) (AFB(1) ) to induce endogenous oxidative damages and the possible ameliorating effects of dietary melatonin (MEL) were investigated. Newly hatched broiler chicks (n = 240) were fed aflatoxin-contaminated diets (0.5 or 1 mg kg(-1) diet) with or without MEL (40 mg kg(-1) bw) supplementation in diet for 40 days. AFB(1) resulted in a significant increase in lipid peroxidation (LPO) in the liver and erythrocytes accompanied with suppression of superoxide dismutase (SOD) and catalase (CAT) enzyme activities of erythrocytes. It also caused a significant reduction in levels of serum proteins and marked elevation in activities of serum transaminases. AFB(1) treatment also decreased both humoral and cell-mediated immune responses in growing chicks. Simultaneous administration of MEL with AFB(1) resulted in an obvious improvement in all the tested parameters. Long-term rather than short-term administration of MEL was more effective in rendering protection against AFB(1) -induced toxicity. © 2009 Wiley Periodicals, Inc. Environ Toxicol 26: 153-160, 2011. |
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Authors:
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M Sirajudeen; Kandasamy Gopi; Jagbir Singh Tyagi; Ram Phal Moudgal; Jag Mohan; Ram Singh |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental toxicology Volume: 26 ISSN: 1522-7278 ISO Abbreviation: Environ. Toxicol. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100885357 Medline TA: Environ Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 153-60 Citation Subset: IM |
Copyright Information:
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Copyright © 2009 Wiley Periodicals, Inc. |
Affiliation:
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Division of Physiology and Reproduction, Central Avian Research Institute, Izatnagar 243122, India. shiraz.m@rediff.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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