| Protective effects of lycopene and tomato extract against doxorubicin-induced cardiotoxicity. | |
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MedLine Citation:
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PMID: 16261525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The protective effect of tomato extract and lycopene on acute doxorubicin (DOX) myocardial toxicity was evaluated in mice. DOX toxicity, induced by a single intraperitoneal injection (15 mg/kg), was revealed by an elevated serum CPK(MB) and histopathological observations. Tomato extract (1.2 and 2.4 g/kg, i.p.) and lycopene (1.7 and 3.5 mg/kg, i.p.) prevented the rise in serum CPK(MB) and ameliorated cardiac cell injury. These results suggest that tomato extract and lycopene inhibit DOX cardiotoxicity and might serve as a novel combination chemotherapeutic agent with DOX to limit free radical-mediated organ injury. |
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Authors:
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Gholamreza Karimi; Mohammad Ramezani; Azadeh Abdi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Phytotherapy research : PTR Volume: 19 ISSN: 0951-418X ISO Abbreviation: Phytother Res Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-11-07 Completed Date: 2005-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
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Languages: eng Pagination: 912-4 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2005 John Wiley & Sons, Ltd. |
Affiliation:
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Department of Pharmacodynamy and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Gho_karimi@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antibiotics, Antineoplastic / diagnostic use Carotenoids / administration & dosage, pharmacology, therapeutic use Creatine Kinase / blood, metabolism Doxorubicin / diagnostic use Free Radical Scavengers / administration & dosage, pharmacology*, therapeutic use Injections, Intraperitoneal Lycopersicon esculentum* Male Mice Mice, Inbred BALB C Myocardium / metabolism*, pathology Phytotherapy* Plant Extracts / administration & dosage, pharmacology*, therapeutic use Protective Agents / administration & dosage, pharmacology*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Free Radical Scavengers; 0/Plant Extracts; 0/Protective Agents; 23214-92-8/Doxorubicin; 36-88-4/Carotenoids; 502-65-8/lycopene; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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