| Protective effects of lithium treatment for spatial memory deficits induced by tau hyperphosphorylation in splenectomized rats. | |
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MedLine Citation:
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PMID: 20659131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Postoperative cognitive dysfunction has become more prevalent in recent years. We used a splenectomized rat model with postoperative spatial learning and memory deficits to investigate the role of tau hyperphosphorylation and glycogen synthase kinase-3β (GSK-3β) within the hippocampus. 2. Cognitive function was assessed in a Y-maze 1 day before and 1, 3 and 7 days after surgery. We measured site-specific phosphorylation of hippocampal tau (Thr-205 and Ser-396), GSK-3β activity and expression of interleukin-1β (IL-1β), tumour necrosis factor-α (TNF-α) mRNA and protein as markers of inflammation. We also tested the effects of treatment with lithium chloride (LiCl), a GSK-3β inhibitor. 3. Splenectomy was associated with learning and memory impairment 3 days later, as well as a rapid and massive hyperphosphorylation of hippocampal tau at Thr-205 and Ser-396, activated GSK-3β, and increased IL-1β and TNF-α expression. LiCl completely restored tau hyperphosphorylation to control levels. 4. These data from the splenectomized rat model suggest that inflammatory factors affect tau pathology through the GSK-3β signalling pathway and that LiCl is a promising treatment for postoperative cognitive deficits. |
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Authors:
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Wen-Fei Tan; Xue-Zhao Cao; Jun-Ke Wang; Huang-Wei Lv; Bin-Yang Wu; Hong Ma |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and experimental pharmacology & physiology Volume: 37 ISSN: 1440-1681 ISO Abbreviation: Clin. Exp. Pharmacol. Physiol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-09-02 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0425076 Medline TA: Clin Exp Pharmacol Physiol Country: Australia |
Other Details:
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Languages: eng Pagination: 1010-5 Citation Subset: IM |
Copyright Information:
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© 2010 The Authors. Clinical and Experimental Pharmacology and Physiology © 2010 Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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Department of Anaesthesiology, First Hospital of China Medical University, Shenyang, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / metabolism Glycogen Synthase Kinase 3 / antagonists & inhibitors, physiology Inflammation Mediators / metabolism, therapeutic use Lithium Chloride / therapeutic use* Male Maze Learning / drug effects, physiology Memory Disorders / metabolism*, pathology, prevention & control* Neuroprotective Agents / therapeutic use* Phosphorylation / drug effects, physiology Postoperative Complications / metabolism, pathology, prevention & control* Rats Rats, Sprague-Dawley Signal Transduction / drug effects, physiology Splenectomy / adverse effects* Treatment Outcome tau Proteins / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Neuroprotective Agents; 0/tau Proteins; 7447-41-8/Lithium Chloride; EC 2.7.11.1/glycogen synthase kinase 3 beta; EC 2.7.11.26/Glycogen Synthase Kinase 3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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