Document Detail


Protective effects of heparin on hepatic ischemia and reperfusion lesions in rabbits.
MedLine Citation:
PMID:  19376359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because the role of heparin (HEP) in hepatic ischemia/reperfusion (I/R) injury is still not fully understood, we investigated the effects of treatment with HEP on hepatic I/R injury in rabbits. For I/R procedures, the portal vein and hepatic artery were occluded by a metallic clamp to promote ischemia. The clamp was removed after 30 minutes to allow reperfusion. Rabbits undergoing the I/R procedure were treated with HEP (100 U/kg) or saline solution 0.9% (SS). When compared with levels before I/R, the serum aspartate aminotransferase, alanine aminotransferase, and lactate dehydrogenase, levels were increased by the hepatic I/R procedure, among rabbits treated with SS or HEP. However, the increase in these enzymes was lower among rabbits treated with HEP. Histologic analysis of hepatic tissue of rabbits undergoing I/R and treated with SS showed marked lesions in the central lobule with significant inflammatory infiltration. In contrast, a significant reduction in lesions caused by I/R was observed in the livers of rabbits treated with HEP. After starting reperfusion, we visualized apoptotic cells with nuclear staining among rabbits submitted to I/R and treated with SS, but not those treated with HEP. These results suggested that HEP was able to attenuate hepatic lesions caused by I/R in the livers of rabbits.
Authors:
M O Taha; P F Z R A Gon?alves; R O G Vidigal; G P S Sacchi; F G Pinheiro; L S G Brand?o; S Feguri; A M Moraes-Filho; M M Ghadie; K G Magalh?es; M J Sim?es; I L S Tersariol; H P Monteiro; I S Oliveira-J?nior; I Oliveira; A Jurkiewicz; A Caricati-Neto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Transplantation proceedings     Volume:  41     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-07-29     Revised Date:  2010-06-15    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  812-5     Citation Subset:  IM    
Affiliation:
Department of Surgery, Federal University of S?o Paulo, Escola Paulista de Medicina, S?o Paulo, Brazil. taha@uol.com.br
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MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / drug effects,  metabolism
Animals
Aspartate Aminotransferases / drug effects,  metabolism
Disease Models, Animal
Fibrinolytic Agents / therapeutic use
Heparin / therapeutic use*
Ischemia / drug therapy*,  enzymology
L-Lactate Dehydrogenase / drug effects,  metabolism
Liver / enzymology
Liver Diseases / drug therapy*,  enzymology
Male
Rabbits
Reperfusion Injury / enzymology,  prevention & control*
Chemical
Reg. No./Substance:
0/Fibrinolytic Agents; 9005-49-6/Heparin; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase
Comments/Corrections
Erratum In:
Transplant Proc. 2010 May;42(4):1385
Note: Oliveira, I Jr [corrected to Oliveira-J?nior, I S]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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