Document Detail

Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils.
MedLine Citation:
PMID:  10863027     Owner:  NLM     Status:  MEDLINE    
Recent studies have shown that green tea polyphenols reduce free radical-induced lipid peroxidation. Oxygen free radical injury plays an important role in neuronal damage induced by brain ischemia and reperfusion. The purpose of this study was to examine whether (-)-epigallocatechin gallate (EGCG) would reduce neuronal damage after transient global ischemia in the gerbils because EGCG has a potent antioxidant property as a green tea polyphenol. To produce transient global ischemia, both common carotid arteries were occluded for 3 min with microaneurysmal clips. The gerbils were treated with EGCG (10, 25, or 50 mg/kg, i.p.) immediately after ischemia. Neuronal cell damage in the hippocampal CA1 region was evaluated quantitatively 5 days after ischemia by a blinded investigator. EGCG at the dose of 10 mg/kg failed to reduce hippocampal neuronal damage. However, EGCG when administered at the dose of 25 or 50 mg/kg significantly reduced hippocampal neuronal damage in a dose-dependent manner (P<0.001, respectively). The present results show that the green tea polyphenol, EGCG, has a neuroprotective effect against neuronal damage following global ischemia in the gerbils.
S Lee; S Suh; S Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  287     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-01     Completed Date:  2000-09-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  191-4     Citation Subset:  IM    
Department of Pharmacology, School of Medicine, Keimyung University, Taegu, South Korea.
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MeSH Terms
Antioxidants / pharmacology
Catechin / analogs & derivatives*,  pharmacology
Dose-Response Relationship, Drug
Free Radical Scavengers / pharmacology*
Hippocampus / blood supply,  cytology,  metabolism*
Ischemic Attack, Transient / drug therapy*,  metabolism*
Lipid Peroxidation / drug effects
Neurons / metabolism
Neuroprotective Agents / pharmacology
Reg. No./Substance:
0/Antioxidants; 0/Free Radical Scavengers; 0/Neuroprotective Agents; 0/Tea; 154-23-4/Catechin; 989-51-5/epigallocatechin gallate

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