Document Detail

Protective effects of glycyrrhizin in a gut hypoxia (ischemia)-reoxygenation (reperfusion) model.
MedLine Citation:
PMID:  18953525     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study investigated the effects of glycyrrhizin, a potent antioxidant, on tissue injury caused by ischemia/reperfusion (I/R) of the gut. METHODS: I/R injury of the intestine was caused by clamping both the superior mesenteric artery and the celiac trunk for 45 min followed by release of the clamp allowing reperfusion for 1 or 6 h. RESULTS: Administration of glycyrrhizin, significantly reduced the (a) fall of mean arterial blood pressure, (b) mortality rate, (c) myeloperoxidase (MPO) activity, (d) production of pro-inflammatory cytokines [tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta)], (e) histological evidence of gut injury, (f) immunoreactivity of nitrotyrosine, (g) poly ADP-ribose (PAR) formation, (h) the expression of ICAM-1 and P-selectin, (i) activation of nuclear factor-kappaB (NF-kappaB) and (j) signal transducer and activator transcription-3 (STAT-3) induced by splanchnic artery occlusion-reperfusion shock. CONCLUSIONS: This study demonstrates that glycyrrhizin exerts multiple protective effects in splanchnic artery occlusion-reperfusion shock.
Rosanna Di Paola; Marta Menegazzi; Emanuela Mazzon; Tiziana Genovese; Concetta Crisafulli; Martina Dal Bosco; Zhenzhen Zou; Hisanori Suzuki; Salvatore Cuzzocrea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-25
Journal Detail:
Title:  Intensive care medicine     Volume:  35     ISSN:  1432-1238     ISO Abbreviation:  Intensive Care Med     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-18     Completed Date:  2009-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  687-97     Citation Subset:  IM    
IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy.
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MeSH Terms
Anti-Inflammatory Agents / pharmacology*,  therapeutic use*
Gastrointestinal Tract / drug effects*,  injuries*,  metabolism
Glycyrrhizic Acid / pharmacology*,  therapeutic use*
Hypertension / drug therapy
Intercellular Adhesion Molecule-1 / metabolism
Interleukin-1beta / metabolism
Malondialdehyde / metabolism
Neutrophils / metabolism
P-Selectin / metabolism
Peroxidase / metabolism
Rats, Sprague-Dawley
Reperfusion Injury / drug therapy*,  metabolism*
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Interleukin-1beta; 0/P-Selectin; 0/Tumor Necrosis Factor-alpha; 126547-89-5/Intercellular Adhesion Molecule-1; 1405-86-3/Glycyrrhizic Acid; 542-78-9/Malondialdehyde; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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