Document Detail


Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats.
MedLine Citation:
PMID:  18358653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM OF THE STUDY: To investigate the protective effects of dehydrocavidine (DC), a main active ingredient of Corydalis saxicola Bunting (Yanhuanglian), on carbon tetrachloride (CCl4)-induced hepatotoxicity and the possible mechanisms involved in male Sprague-Dawley rats. MATERIALS AND METHODS: Acute hepatotoxicity was induced by CCl4 intoxication in rats. Serum biological analysis, lipid peroxides and antioxidants estimation, histopathological studies were carried out. RESULTS: Both pre-treatment with DC prior to CCl4 administration and post-treatment with DC after CCl4 administration significantly prevented increases in serum enzymatic activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) and total bilirubin (TBIL). In addition, pre- and post-treatment with DC also significantly prevented formation of hepatic malondialdehyde (MDA), depletion of glutathione peroxidase (GPx) and depression of superoxide dismutase (SOD) in the liver of CCl4-intoxicated rats. ALT, AST, LDH, ALP and TBILL levels, as well as MDA, SOD and GPx activities were unaffected in normal rats by treatment with DC alone. GST, a phase II enzyme, had no significant changes during our experiments. Histopathological changes induced by CCl4 were also significantly attenuated by DC treatment in both preventive and curative experiments. CONCLUSIONS: DC has a potent hepatoprotective effect on CCl4-induced liver injury in rats through its antioxidant activity.
Authors:
Tao Wang; Ning-Ling Sun; Wei-Dong Zhang; Hui-Liang Li; Guo-Cai Lu; Bo-Jun Yuan; Hua Jiang; Jia-Hong She; Chuan Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-14
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  117     ISSN:  0378-8741     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-21     Completed Date:  2008-09-26     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  300-8     Citation Subset:  IM    
Affiliation:
Center for New Drug Evaluation, Institute of Basic Medical Science, Second Military Medical University, No 800 Xiang Yin Road, Shanghai 200433, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology
Berberine Alkaloids / pharmacology*
Carbon Tetrachloride Poisoning / prevention & control*
Crystallization
Drug-Induced Liver Injury / prevention & control*
Glutathione / metabolism
Glutathione Transferase / metabolism
Lipid Peroxidation / drug effects
Liver / drug effects,  enzymology,  metabolism
Liver Function Tests
Male
Plant Extracts / chemistry,  pharmacology
Rats
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Berberine Alkaloids; 0/Plant Extracts; 32728-75-9/cavidine; 70-18-8/Glutathione; EC 1.15.1.1/Superoxide Dismutase; EC 2.5.1.18/Glutathione Transferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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