Document Detail

Protective effects of cysteine, methionine and vitamin C on the stomach in chronically alcohol treated rats.
MedLine Citation:
PMID:  17966116     Owner:  NLM     Status:  MEDLINE    
A chronic intake of high dose alcohol may cause oxidative stress and inflammation in the stomach. It is hypothesized that cysteine-methionine and vitamin C may neutralize harmful compounds while potentiating the antioxidant capacity of the cell or tissue. The experimental animals were fed regular diets and were maintained for 90 days in the control group, the alcoholic group, which was given 2.5 g of 50% ethanol kg(-1) body wt. administered intragastrically every other day, or the alcoholic with antioxidant supplement group, to whom 2.5 g of 50% ethanol kg(-1) body wt. + a solution that contained 200 mg vitamin C, 100 mg cysteine and 100 mg methionine was administered intragastrically every other day. After the treatments, the stomach was taken for pathological and biochemical analysis. The stomach of the alcoholic group rats had higher scores of pathological findings compared with the control group, whereas the scores of the antioxidant-supplemented group were lower than the alcoholic group. In addition, the oxidized protein and lipid content in the stomachs of the alcoholic group were significantly higher than the control, but antioxidant supplementation lowered the amount of oxidation in the antioxidant supplemented group. The amount of stomach glutathione in the alcoholic group was higher than that of the control and antioxidant-supplemented groups. Interestingly, the level of total thiol in the stomach tissue of rats with antioxidant supplement was statistically higher than that of the control and alcoholic groups. In conclusion, the scores of the pathological findings in the stomach of rats with the antioxidant supplement were lower than the chronic alcohol-treated rats, albeit the amount of total thiol was increased in this group. Moreover, chronic alcohol treatment led to an increase in the level of lipid and protein oxidation in the stomach tissue of rats. A simultaneous intake of ascorbate/l-cys/l-met along with ethanol attenuated the amount of oxidation which suggested that cysteine-methionine and vitamin C could play a protective role in the stomach against oxidative damage resulting from chronic alcohol ingestion.
Ramazan Amanvermez; Ozgür K Tunçel; Serif Demir; Mehmet Kefeli; Yüksel Bek; Cemil Celik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied toxicology : JAT     Volume:  28     ISSN:  0260-437X     ISO Abbreviation:  J Appl Toxicol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8109495     Medline TA:  J Appl Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  591-8     Citation Subset:  IM    
Copyright Information:
2008 John Wiley & Sons, Ltd
Department of Biochemistry, School of Medicine, Ondokuz Mayis University, 55139 Samsun, Turkey.
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MeSH Terms
Acetaldehyde / metabolism
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Central Nervous System Depressants*
Cysteine / pharmacology*
Free Radicals / metabolism
Gastric Mucosa / pathology
Glutathione / metabolism
Lipid Peroxidation / drug effects
Methionine / pharmacology*
Rats, Wistar
Stomach Ulcer / chemically induced,  pathology,  prevention & control*
Reg. No./Substance:
0/Antioxidants; 0/Central Nervous System Depressants; 0/Free Radicals; 50-81-7/Ascorbic Acid; 52-90-4/Cysteine; 63-68-3/Methionine; 64-17-5/Ethanol; 70-18-8/Glutathione; 75-07-0/Acetaldehyde

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