| Protective effects of PPAR{gamma} agonist in acute nephrotic syndrome. | |
| | |
MedLine Citation:
|
PMID: 21565943 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background Peroxisome proliferator-activated receptor gamma (PPARγ) agonists have beneficial effects on renal structure and function in models of diabetes and chronic kidney diseases. However, the increased incidence of weight gain and edema potentially limits their usefulness. We studied an acute minimal-change disease-like nephrotic syndrome model to assess effects of PPARγ agonist on acute podocyte injury and effects on fluid homeostasis. Methods Acute podocyte injury and nephrotic syndrome were induced by puromycin aminonucleoside (PAN) injection in rats. Results PPARγ agonist, given at the time or after, but not before PAN, reduced proteinuria, restored synaptopodin, decreased desmin and trended to improve foot process effacement. There was no significant difference in glomerular filtration, effective circulating volume, blood pressure or fractional sodium excretion. PAN-injured podocytes had decreased PPARγ, less nephrin and α-actinin-4, more apoptosis and reduced phosphorylated Akt. In PAN-injured cultured podocytes, PPARγ agonist also reversed abnormalities only when given simultaneously or after injury. Conclusions These results show that PPARγ agonist has protective effects on podocytes in acute nephrotic syndrome without deleterious effects on fluid homeostasis. PPARγ agonist-induced decrease in proteinuria in acute nephrotic syndrome is dependent at least partially on regulation of peroxisome proliferator-response element-sensitive gene expression such as α-actinin-4 and nephrin and the restoration of podocyte structure. |
| | |
Authors:
|
Yiqin Zuo; Hai-Chun Yang; Sebastian A Potthoff; Behzad Najafian; Valentina Kon; Li-Jun Ma; Agnes B Fogo |
Related Documents
:
|
21212573 - A case of cervical cancer-related membranous nephropathy treated with radiation therapy. 21353143 - Potentiating effect of fluphenazine decanoate and risperidone on development of neurole... 17992143 - Individualized implant-based reconstruction of poland syndrome breast and soft tissue d... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-12 |
Journal Detail:
|
Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: - ISSN: 1460-2385 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Atypical electrophysiological activity during pain observation in amputees who experience synaesthet...
Next Document: Chromosomally integrated human herpesvirus-6 in kidney transplant recipients.