| Protective effects of Beta glucan and gliclazide on brain tissue and sciatic nerve of diabetic rats induced by streptozosin. | |
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MedLine Citation:
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PMID: 22291696 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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There have not been yet enough studies about effects of beta glucan and gliclazide on oxidative stress created by streptozotocin in the brain and sciatic nerve of diabetic rats. The aim of this paper was to investigate the antioxidant effects of gliclazide and beta glucan on oxidative stress and lipid peroxidation created by streptozotosin in brain and sciatic nerve. Total of 42 rats were divided into 6 groups including control, diabetic untreated (DM) (only STZ, diabetic), STZ (DM) + beta glucan, STZ (DM) + gliclazide, only beta glucan treated (no diabetic), and only gliclazide treated (no diabetic). The brain and sciatic nerve tissue samples were analyzed for malondialdehyde (MDA), total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI), and paraoxonase (PON-1) levels. We found a significant increase in MDA, TOS, and OSI along with a reduction in TAS level, catalase, and PON-1 activities in brain and sciatic nerve of streptozotocin-induced diabetic rats. Also, this study shows that in terms of these parameters both gliclazide and beta glucan have a neuroprotective effect on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. Our conclusion was that gliclazide and beta glucan have antioxidant effects on the brain and sciatic nerve of the streptozotocin-induced diabetic rat. |
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Authors:
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Harun Alp; Sefer Varol; Muhammet Murat Celik; Murat Altas; Osman Evliyaoglu; Orhan Tokgoz; Mehmet Halis Tanrıverdi; Ertugrul Uzar |
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Publication Detail:
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Type: Journal Article Date: 2012-01-16 |
Journal Detail:
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Title: Experimental diabetes research Volume: 2012 ISSN: 1687-5303 ISO Abbreviation: Exp Diabetes Res Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274844 Medline TA: Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 230342 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Veterinary Faculty, Dicle University, 21103 Diyarbakir, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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