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Protective effects of Asparagus racemosus on oxidative damage in isoniazid-induced hepatotoxic rats: an in vivo study.
MedLine Citation:
PMID:  21724661     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To investigate the hepatoprotective activity of Asparagus racemosus against isoniazid-induced hepatotoxicity in male albino rats. Rats (n = 6 per group) were divided into four groups: saline-treated control, saline-treated control with A. racemosus extract (50 mg/kg), isoniazid treatment alone (100 mg/kg, intraperitoneal [i.p.]), and isoniazid-A. racemosus extract (50 mg/kg) administered orally as cotreatment. Animals were treated for 21 days and euthanized 1 h after the last drug administration. Evaluated body weight, serum levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, g-glutamyl transferase, total protein, albumin, hepatic malondialdehyde content, superoxide dismutase, catalase, cytochrome P450 2E1 (CYP2E1) activity and glutathione (GSH). A. racemosus extract prevented isoniazid-induced hepatotoxicity, indicated by both diagnostic indicators of liver damage, liver functional profile, significantly (p < 0.05) inhibited CYP2E1 activity, markedly attenuated oxidative stress by improved enzymatic, non-enzymatic antioxidants levels and mitigate malondialdehyde, lipid hydroperoxide significantly (p < 0.05). These results suggest that A. racemosus extract exerts its hepatoprotective activity by inhibiting the production of free radicals and acts as a scavenger, reducing the free radical generation via inhibition of hepatic CYP2E1 activity, increasing the removal of free radicals through the induction of antioxidant enzymes and improving non-enzymatic thiol antioxidant GSH.
Authors:
N Palanisamy; S Manian
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-1
Journal Detail:
Title:  Toxicology and industrial health     Volume:  -     ISSN:  1477-0393     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Biochemistry, Centre for Biological Sciences, KSR College of Arts and Science, Tiruchegode, Tamil Nadu, India.
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