Document Detail

Protective effect of yogurt extract on dental enamel demineralization in vitro.
MedLine Citation:
PMID:  19133946     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Casein phosphopeptides (CPPs) are phosphorylated casein-derived peptides produced synthetically by proteolytic digestion of alpha(s1)-, alpha(s2)- and beta-casein. The anticariogenic activity of CPPs is due to their ability to stabilize high levels of amorphous calcium phosphate (ACP) on tooth surface, preventing demineralization and enhancing remineralization of enamel caries. The aim of this study was to test the in vitro ability of natural CPPs (contained in yogurt) to prevent demineralization and promote remineralization of dental enamel. METHODS: Eighty human molars were used. After standardizing an in vitro demineralization procedure for producing artificial caries (Group 1: pH 4.8; Group 2: pH 3.97), this procedure was used on teeth, but with the addition of natural CPPs (Group 3: pH 4.8; Group 4: pH 3.97). The effects of these procedures were evaluated by quantitative analysis (change in weight and calcium titration) and qualitative analysis (SEM). Statistical analysis of the results was performed using ANOVA. RESULTS: Statistical analysis showed significant differences in weight changes between the groups with and without natural CPPs. The SEM observation showed the protective effects of natural CPPs. CONCLUSIONS: The results demonstrated that CPPs contained in yogurt have an inhibitory effect on demineralization and promote the remineralization of dental enamel.
G F Ferrazzano; T Cantile; M Quarto; A Ingenito; L Chianese; F Addeo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Australian dental journal     Volume:  53     ISSN:  0045-0421     ISO Abbreviation:  Aust Dent J     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370612     Medline TA:  Aust Dent J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  314-9     Citation Subset:  D; IM    
Department of Paediatric Dentistry, School of Dentistry, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Calcium Phosphates / chemistry*
Cariostatic Agents / therapeutic use*
Caseins / therapeutic use*
Dental Enamel / metabolism
Peptide Fragments / therapeutic use*
Tooth Demineralization / prevention & control*
Tooth Remineralization / methods
Reg. No./Substance:
0/Calcium Phosphates; 0/Cariostatic Agents; 0/Caseins; 0/Peptide Fragments; 0/amorphous calcium phosphate; 0/caseinophosphopeptide 1-25

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