Document Detail

Protective effect of vitamin E on intraventricular haemorrhage in the newborn.
MedLine Citation:
PMID:  6360588     Owner:  NLM     Status:  MEDLINE    
Forty-four consecutively born babies of birth weights under 1751 g were randomly selected to receive a daily intramuscular injection of vitamin E (all-rac-alpha-tocopheryl acetate) from the day of birth (Day 0) until Day 3, or were allocated to a non-supplemented control group. Frequent ultrasound examinations of the brain were made during the first week of life and babies were classified as having 'no haemorrhage', 'subependymal haemorrhage (SEH) only' or 'intraventricular haemorrhage' (IVH). The incidence of SEH or IVH was similar in supplemented (42.9%) and control babies (43.5%). SEH or IVH was observed only in babies of less than 32 weeks gestation; when only babies under 32 weeks were considered, IVH was less common in those supplemented (18.8%) than in the controls (56.3%). Babies with IVH had lower median plasma vitamin E concentrations when compared with babies without any haemorrhage and compared with those with only SEH. Three supplemented babies suffered IVH and they were the three with the lowest plasma vitamin E concentrations among the babies supplemented with vitamin E from Day 0 to Day 3. We speculate that vitamin E protects endothelial cell membranes of capillaries in the subependymal layer of the brain against oxidative damage and disruption and thereby limits the magnitude of haemorrhage in the subependymal layer, and reduces the risk of extension into the ventricles.
M L Chiswick; M Johnson; C Woodhall; M Gowland; J Davies; N Toner; D Sims
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Publication Detail:
Type:  Clinical Trial; Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Ciba Foundation symposium     Volume:  101     ISSN:  0300-5208     ISO Abbreviation:  Ciba Found. Symp.     Publication Date:  1983  
Date Detail:
Created Date:  1984-02-14     Completed Date:  1984-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0356636     Medline TA:  Ciba Found Symp     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  186-200     Citation Subset:  IM    
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MeSH Terms
Cerebral Hemorrhage / diagnosis,  prevention & control*
Cerebral Ventricles
Clinical Trials as Topic
Hemolysis / drug effects
Hydrogen Peroxide / pharmacology
Infant, Low Birth Weight
Infant, Newborn
Vitamin E / blood,  therapeutic use*
Reg. No./Substance:
1406-18-4/Vitamin E; 7722-84-1/Hydrogen Peroxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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