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Protective effect of vanillin against carbon tetrachloride (CCl4)-induced oxidative brain injury in rats.
MedLine Citation:
PMID:  21986887     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl(4)) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl(4) toxication groups received a single injection of CCl(4) (1 ml/kg, i.p.; CCl(4) and Va + CCl(4) groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO(2) and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl(4) in rats.
Authors:
Mohamed Makni; Yassine Chtourou; Mohamed Barkallah; Hamadi Fetoui
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-10
Journal Detail:
Title:  Toxicology and industrial health     Volume:  -     ISSN:  1477-0393     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8602702     Medline TA:  Toxicol Ind Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia.
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