| Protective effect of a traditional Japanese medicine Hochu-ekki-to (Chinese name: Bu-zhong-yi-qi-tang), on the susceptibility against Listeria monocytogenes in infant mice. | |
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MedLine Citation:
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PMID: 11562059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, the effect of traditional Japanese (Chinese) medicine, Hochu-ekki-to, HOT (Chinese name: Bu-zhong-yi-qi-tang), on the susceptibility against Listeria monocytogenes in postneonatal infant mice was examined. Numbers of bacteria in infant mice (infected at 4 weeks of age) were significantly higher than those in adult mice (infected at 8 weeks of age) on day 3 (non-specific resistance phase) and day 5 (specific resistance phase) after infection. Oral administration of 1,000 mg/kg of HOT for 7 days to infant mice reduced bacterial numbers in the liver and spleen at 5 days after the infection. The amount of IFN-gamma and the number of IFN-gamma-producing CD4+ T cells were lower in infant mice than adult mice but those in infant mice enhanced by HOT treatment. HOT also enhanced the antigen-presenting function along with the expression of MHC class II in infant macrophages induced by heat-killed L. monocytogenes. Further, HOT enhanced the IFN-gamma production from infant CD4+ T cells independent of the deficiency in the antigen-presenting function. These findings suggest that HOT induced simultaneously functional maturation of both infant antigen-presenting cells and T cells, and consequently developed an anti-listerial Th1 response. |
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Authors:
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Y Yamaoka; T Kawakita; K Nomoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International immunopharmacology Volume: 1 ISSN: 1567-5769 ISO Abbreviation: Int. Immunopharmacol. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-19 Completed Date: 2002-02-26 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100965259 Medline TA: Int Immunopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1669-77 Citation Subset: IM |
Affiliation:
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Kampo (Traditional Japanese Medicine) and Healthcare Research Laboratories, Kanebo Co. Ltd, Takaoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn / physiology* Antigen-Presenting Cells / immunology Antigens, CD4 / immunology Cell Count Colony Count, Microbial Drugs, Chinese Herbal / therapeutic use* Female Interferon-gamma / biosynthesis Listeria Infections / microbiology, prevention & control* Mice Mice, Inbred BALB C Phytotherapy* T-Lymphocytes / drug effects, immunology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/Drugs, Chinese Herbal; 0/bu-zhong-yi-qi-tang; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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