Document Detail

Protective effect of taurine on the detachment of cultured cardiac fibroblasts from the substratum induced by calcium depletion.
MedLine Citation:
PMID:  15042445     Owner:  NLM     Status:  MEDLINE    
Removal of Ca2+ from the incubation medium of cultured rat cardiac fibroblasts causes cellular morphological changes, such as the formation of blebs, the ballooning of the cell membrane and the detachment from the culture dish. A 24 hr preincubation with 20 mM taurine blocked the Ca2+ depletion-induced detachment of the cardiac fibroblasts. However, taurine treatment did not prevent other morphological changes induced by Ca2+ depletion. The data suggest that taurine plays an important role in cell adhesion in the heart.
M Azuma; K Takahashi; A Kimura; T Matsuda; S W Schaffer; J Azuma
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Publication Detail:
Type:  Journal Article     Date:  2003-10-17
Journal Detail:
Title:  Amino acids     Volume:  26     ISSN:  0939-4451     ISO Abbreviation:  Amino Acids     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-25     Completed Date:  2004-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871 Osaka, Japan.
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MeSH Terms
Calcium / pharmacology*,  physiology
Calcium Channel Blockers / pharmacology*
Cell Adhesion / drug effects
Cells, Cultured
Fibroblasts / cytology,  drug effects*
Myocardium / cytology
Rats, Wistar
Taurine / pharmacology*
Reg. No./Substance:
0/Calcium Channel Blockers; 107-35-7/Taurine; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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