Document Detail


Protective effect of taurine against doxorubicin-induced cardiotoxicity in perfused chick hearts.
MedLine Citation:
PMID:  2626399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of taurine to protect the isolated heart against doxorubicin cardiotoxicity was examined. Chick hearts perfused for 20 min with medium containing 17 microM doxorubicin exhibited a decrease in contractility, an increase in resting tension and a dramatic depletion in tissue high energy phosphate content. Addition of 20 mM taurine to the perfusate attenuated the increase in resting tension and the decrease in myocardial adenosine triphosphate content induced by doxorubicin. The present study confirms our previous in vivo observations that taurine partially prevents doxorubicin-induced cardiotoxicity.
Authors:
T Hamaguchi; J Azuma; H Harada; K Takahashi; S Kishimoto; S W Schaffer
Related Documents :
6829399 - Regional myocardial perfusion at rest and during intracoronary papaverine in patients w...
3805519 - Intracoronary thallium-201 scintigraphy after thrombolytic therapy for acute myocardial...
17703339 - Predicting breast attenuation in patients undergoing myocardial perfusion scintigraphy:...
20421799 - Quantitative whole heart stress perfusion ct imaging as noninvasive assessment of hemod...
8737209 - Myocardial contrast echocardiography in acute myocardial infarction. pathophysiological...
9088939 - Contrast echocardiography for assessment of myocardial perfusion.
11329759 - Angiotensin ii-receptor blockers: clinical relevance and therapeutic role.
8393389 - Lisinopril lowers cardiac adrenergic drive and increases beta-receptor density in the f...
16142599 - Cardiac preconditioning during percutaneous coronary interventions.
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  21     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-04-12     Completed Date:  1990-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Osaka University Medical School, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenine Nucleotides / metabolism
Animals
Chickens
Doxorubicin / antagonists & inhibitors*
Heart / drug effects*
Myocardial Contraction / drug effects
Myocardium / metabolism
Perfusion
Taurine / pharmacology*
Chemical
Reg. No./Substance:
0/Adenine Nucleotides; 107-35-7/Taurine; 23214-92-8/Doxorubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes of vascular smooth muscle reactivity in hypertensive rats.
Next Document:  Perspectives in oral health in families in Mexico state