Document Detail

Protective effect of taurine against doxorubicin-induced cardiotoxicity in perfused chick hearts.
MedLine Citation:
PMID:  2626399     Owner:  NLM     Status:  MEDLINE    
The ability of taurine to protect the isolated heart against doxorubicin cardiotoxicity was examined. Chick hearts perfused for 20 min with medium containing 17 microM doxorubicin exhibited a decrease in contractility, an increase in resting tension and a dramatic depletion in tissue high energy phosphate content. Addition of 20 mM taurine to the perfusate attenuated the increase in resting tension and the decrease in myocardial adenosine triphosphate content induced by doxorubicin. The present study confirms our previous in vivo observations that taurine partially prevents doxorubicin-induced cardiotoxicity.
T Hamaguchi; J Azuma; H Harada; K Takahashi; S Kishimoto; S W Schaffer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacological research : the official journal of the Italian Pharmacological Society     Volume:  21     ISSN:  1043-6618     ISO Abbreviation:  Pharmacol. Res.     Publication Date:    1989 Nov-Dec
Date Detail:
Created Date:  1990-04-12     Completed Date:  1990-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8907422     Medline TA:  Pharmacol Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  729-34     Citation Subset:  IM    
Third Department of Internal Medicine, Osaka University Medical School, Japan.
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MeSH Terms
Adenine Nucleotides / metabolism
Doxorubicin / antagonists & inhibitors*
Heart / drug effects*
Myocardial Contraction / drug effects
Myocardium / metabolism
Taurine / pharmacology*
Reg. No./Substance:
0/Adenine Nucleotides; 107-35-7/Taurine; 23214-92-8/Doxorubicin

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