Document Detail


Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats.
MedLine Citation:
PMID:  2929397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of BM-13505, 4-[2-(4-chlorobenzenesulfonylamino) ethyl]-benzene acetic acid), a specific thromboxane/endoperoxide receptor antagonist, to protect the myocardium against ischemia and reperfusion injury, was assessed in an anesthetized cat model. Cats were rendered ischemic by left anterior descending (LAD) coronary artery ligation for 1 1/2 hours followed by reperfusion for 4 1/2 hours. BM-13505 or its vehicle (i.e., Na2CO3) was administered intravenously 30 minutes before reperfusion at a rate of 1 mg/kg followed by 1 mg/kg/hr. BM-13505 significantly (p less than 0.001) reduced the area of ischemic tissue as a percent of total left ventricular mass and total area at risk, without altering basic hemodynamics (i.e., arterial blood pressure, heart rate, or their product) and thereby not influencing myocardial oxygen demand. The mechanism of the protective effect of the thromboxane receptor antagonist appears to be cytoprotective but may involve the prevention of neutrophil-induced cellular damage.
Authors:
A M Bhat; H Sacks; J A Osborne; A M Lefer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  117     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-03     Completed Date:  1989-05-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  799-803     Citation Subset:  AIM; IM    
Affiliation:
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Blood Pressure / drug effects
Cats
Coronary Disease / enzymology,  physiopathology*
Creatine Kinase / blood
Electrocardiography
Heart Rate / drug effects
Male
Myocardial Reperfusion Injury / pathology,  prevention & control*
Myocardium / pathology
Necrosis
Phenylacetates / therapeutic use*
Sulfonamides / therapeutic use*
Thromboxanes / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
HL-25575/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Phenylacetates; 0/Sulfonamides; 0/Thromboxanes; 105218-03-9/daltroban; EC 2.7.3.2/Creatine Kinase

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