Document Detail


Protective effect of sodium selenite and zinc sulfate on intensive swimming-induced testicular gamatogenic and steroidogenic disorders in mature male rats.
MedLine Citation:
PMID:  18923565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the ameliorative potential of sodium selenite and zinc sulfate on intensive-swimming-induced testicular disorders, 48 Wistar male rats (age, 4 months; mass, 146.2 +/- 3.6 g) were randomly divided into 4 groups: the unexercised-control group (n = 12); the exercised group (n = 12); the control supplemented group (n = 12); and the exercised supplemented group (n = 12). For 10 weeks, the exercised rats underwent a protocol that consisted of 4 h.d-1 swimming, for 6 d.week-1; the control rats did not exercise. For 10 weeks, both the supplemented groups received an oral daily dose of a combination of sodium selenite and zinc sulfate (6 and 3 mg.kg body mass-1, respectively). After 10 weeks, a significant reduction (p < 0.05) was seen in rats in the exercised group, compared with rats in both control groups, in paired testicular masses; in epididymal sperm count; in testicular Delta5, 3beta-hydroxysteroid dehydrogenase (HSD) and 17beta-HSD; in plasma levels of testosterone, luteinizing hormone, follicle-stimulating hormone, and prolactin; in the numbers of preleptotine spermatocytes, midpachytene spermatocytes, and stage 7 spermatids of the stage VII seminiferous epithelium cycle; and in fertility performance. As well, a significant increase (p < 0.05) was seen in the exercised group, compared with both control groups, in plasma corticosterone levels and in testicular content of malondialdehyde and catalase activity. At the same time, there was a significant reduction (p < 0.05) in the exercised group, compared with both control groups, in plasma concentrations of zinc and selenium; in the testicular content of glutathione (GSH), the glutathione and glutathione disulphide (GSSG) ratio, ascorbic acid, and alpha-tocopherol; and in testicular activities of superoxide dismutase, glutathione-peroxidase, and glutathione-S-transferase in the testes. No significant changes were seen in the number of spermatogonia-A from the stage VII seminiferous epithelium cycle or the testicular content of GSSG among the groups. Sodium selenite and zinc sulfate supplementation significantly protected against exercise-induced testicular gamatogenic and spermatogenic disorders, prevented testicular oxidative stress, and increased antioxidant status. It can be concluded that intensive-swimming-induced oxidative stress causes dysfunctions in the male reproductive system, which can be protected by the coadministration of sodium selenite and zinc sulfate.
Authors:
Kuladip Jana; Pravat K Samanta; Indranil Manna; Prasanta Ghosh; Narendra Singh; Ramawatar P Khetan; Binoy R Ray
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Applied physiology, nutrition, and metabolism = Physiologie appliquée, nutrition et métabolisme     Volume:  33     ISSN:  1715-5312     ISO Abbreviation:  -     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2008-12-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264333     Medline TA:  Appl Physiol Nutr Metab     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  903-14     Citation Subset:  IM    
Affiliation:
Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th St., Lubbock, TX 79430, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Corticosterone / blood
Epididymis / cytology,  drug effects
Fertility / drug effects
Follicle Stimulating Hormone / blood
Gametogenesis / drug effects*,  physiology*
Hormones / blood
Lipid Peroxidation / drug effects
Luteinizing Hormone / blood
Male
Organ Size / drug effects
Oxidative Stress / drug effects
Prolactin / blood
Rats
Rats, Wistar
Sodium Selenite / pharmacology*
Sperm Count
Spermatogenesis / drug effects
Steroids / blood*
Swimming / physiology*
Testicular Diseases / etiology*,  prevention & control*
Testis / drug effects,  enzymology
Testosterone / blood
Zinc Sulfate / pharmacology*
Chemical
Reg. No./Substance:
0/Hormones; 0/Steroids; 10102-18-8/Sodium Selenite; 50-22-6/Corticosterone; 58-22-0/Testosterone; 7733-02-0/Zinc Sulfate; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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