Document Detail


Protective effect of sivelestat sodium (Eraspol) on postoperative lung dysfunction in patients with type A acute aortic dissection: a pilot study.
MedLine Citation:
PMID:  18670380     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The authors evaluated the protective effect of sivelestat sodium on postoperative lung dysfunction in patients with type A acute aortic dissection who underwent aortic arch surgery with cardiopulmonary bypass (CPB) under deep hypothermia with circulatory arrest (DHCA). METHODS: Twelve patients with type A acute aortic dissection who underwent aortic arch replacement under CPB with DHCA and were pretreated with or without sivelestat sodium (sivelestat group, N.=7 patients; control group, N.=5 patients) were observed. The ratio of arterial oxygen tension to inspired oxygen fraction (P/F ratio) was measured as a parameter of pulmonary function before and after operation. The number of white blood cells was also counted as an index of inflammatory reaction before and after the operation. RESULTS: The P/F ratio decreased significantly after operation in the control group. However, the P/F ratio was unchanged between before and after operation in the sivelestat group. The number of white blood cells tended to increase after operation in the control group, whereas it decreased significantly after operation in the sivelestat group. CONCLUSION: The present study demonstrated the protective effect of sivelestat sodium on postoperative lung injury in patients with acute type A aortic dissection undergoing aortic arch surgery under CPB with DHCA.
Authors:
T Nishibe; Y Kondo; A Muto; A Dardik; Y Ohara; M Kainuma; K Takeda
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of cardiovascular surgery     Volume:  49     ISSN:  0021-9509     ISO Abbreviation:  J Cardiovasc Surg (Torino)     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-12-16     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0066127     Medline TA:  J Cardiovasc Surg (Torino)     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Surgery, Department of Surgery, Fujita Health University, Toyoake, Japan. toshiyanishibe@yahoo.co.jp
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Analysis of Variance
Aneurysm, Dissecting / surgery*
Aortic Aneurysm, Thoracic / surgery*
Cardiopulmonary Bypass
Chi-Square Distribution
Female
Glycine / analogs & derivatives*,  therapeutic use
Humans
Leukocyte Count
Lung Diseases / prevention & control*
Male
Pilot Projects
Postoperative Complications / prevention & control*
Respiratory Function Tests
Serine Proteinase Inhibitors / therapeutic use*
Sulfonamides / therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Serine Proteinase Inhibitors; 0/Sulfonamides; 127373-66-4/ONO 5046; 56-40-6/Glycine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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