Document Detail

Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity.
MedLine Citation:
PMID:  8600516     Owner:  NLM     Status:  MEDLINE    
Rotaviruses are the leading cause of severe gastroenteritis and dehydrating diarrhea in young children and animals worldwide. A murine model and "backpack tumor" transplantation were used to determine the protective effect of antibodies against VP4(an outer capsid viral protein) and VP6(a major inner capsid viral protein). Only two non-neutralizing immunoglobulin A (IgA) antibodies to VP6 were capable of preventing primary and resolving chronic murine rotavirus infections. These antibodies were not active, however, when presented directly to the luminal side of the intestinal tract. These findings support the hypothesis that in vivo intracellular viral inactivation by secretory IgA during transcytosis is a mechanism of host defense against rotavirus infection.
J W Burns; M Siadat-Pajouh; A A Krishnaney; H B Greenberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  272     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-04-29     Completed Date:  1996-04-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  104-7     Citation Subset:  IM    
Department of Medicine, Stanford University School of Medicine, CA 94305, USA.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage,  immunology*,  metabolism
Antibodies, Viral / administration & dosage,  immunology*,  metabolism
Antigens, Viral*
Capsid / immunology*
Capsid Proteins*
Feces / chemistry,  virology
Ileum / immunology,  virology
Immunization, Passive
Immunoglobulin A, Secretory / administration & dosage,  immunology*,  metabolism
Mice, Inbred BALB C
Mice, SCID
Neutralization Tests
Rotavirus / immunology*,  physiology
Rotavirus Infections / immunology*,  prevention & control,  virology
Virus Replication
Virus Shedding
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Viral; 0/Antigens, Viral; 0/Capsid Proteins; 0/Immunoglobulin A, Secretory; 0/VP6 protein, Rotavirus
Comment In:
Science. 1996 Apr 5;272(5258):46-8   [PMID:  8600533 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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