Document Detail

Protective effect of retinoid against endotoxin-induced mastitis in rats.
MedLine Citation:
PMID:  19184358     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: A lipopolysaccharide (LPS) induced mastitis model in rats was used to study the protective effect of retinoid. MATERIALS AND METHODS: Commencing at gestation day 10, retinoid (dissolved in olive oil) or an equal volume of olive oil was administered to rats daily by gavage until parturition. LPS or pyrogen-free physiological saline was inoculated into the mammary gland 72h after parturition and the rats were euthanized at 12h post-infection. RESULTS: Myeloperoxidase (MPO), N-acetyl -beta-D- glucosaminidase (NAGase), tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8) in mammary tissues and CD4(+)/CD8(+) in peripheral blood were increased and serum MPO and IL-2 in mammary tissues were decreased 12h after LPS infusion. Retinoid decreased MPO, NAGase, and TNF-alpha in mammary tissue and increased IL-2 in serum. Four thousand and 8000 I.U/kg x d of retinoid significantly decreased the infiltration of PMNs in mammary alveoli and ameliorated the imbalance of CD4+/CD8+ in peripheral blood. CONCLUSION: These results suggest that retinoid protected against LPS-induced mastitis in a rat model.
B-B Gu; J-F Miao; Y-M Zhu; Y-E Deng; S-X Zou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Inflammation research : official journal of the European Histamine Research Society ... [et al.]     Volume:  58     ISSN:  1420-908X     ISO Abbreviation:  Inflamm. Res.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508160     Medline TA:  Inflamm Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
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MeSH Terms
Acetylglucosaminidase / metabolism
Anti-Inflammatory Agents / metabolism,  therapeutic use*
Endotoxins / adverse effects*,  immunology
Interleukin-2 / metabolism
Interleukin-8 / metabolism
Lipopolysaccharides / adverse effects*,  immunology
Mastitis / chemically induced,  drug therapy*,  pathology,  veterinary*
Peroxidase / metabolism
Rats, Sprague-Dawley
Retinoids / metabolism,  therapeutic use*
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Endotoxins; 0/Interleukin-2; 0/Interleukin-8; 0/Lipopolysaccharides; 0/Retinoids; 0/Tumor Necrosis Factor-alpha; EC; EC

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