Document Detail


Protective effect of quercetin against sodium fluoride induced oxidative stress in rat's heart.
MedLine Citation:
PMID:  22314573     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The antioxidative and cardioprotective properties of quercetin were investigated against sodium fluoride (NaF) induced oxidative stress in rat hearts. Experimental rats were divided into five groups. The first group served as the untreated (normal) control. The second group received NaF at a dose of 600 ppm through drinking water for 1 week, and served as the toxin control. The third and fourth groups were exposed to quercetin (at the dose of 10 and 20 mg kg(-1) intraperitoneally (i.p.) for 1 week) prior to NaF intoxication, and the fifth group was treated with vitamin C at a dose of 10 mg kg(-1) i.p., for 1 week prior to NaF intoxication and served as the positive control in the study. The activities of various antioxidant enzymes, superoxide dismutase and catalase, level of reduced glutathione and lipid peroxidation end product were determined in the cardiac tissues of all the experimental animals. NaF intoxication significantly altered all the indices related to the pro-oxidant-antioxidant status of the heart; treatment with the active constituents prior to NaF administration, however, prevented these alterations. The combined results suggest that quercetin protects rat hearts from NaF-induced oxidative stress, probably via its antioxidant properties.
Authors:
Seyed Fazel Nabavi; Seyed Mohammad Nabavi; Morteza Mirzaei; Akbar Hajizadeh Moghaddam
Related Documents :
3181363 - The fate of prelabeled clarke's column neurons after axotomy.
12196533 - The general anesthetic pentobarbital slows desensitization and deactivation of the glyc...
193093 - The effect of apomorphine, amantadine and dimethylaminoadamantane on the level of cycli...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-8
Journal Detail:
Title:  Food & function     Volume:  -     ISSN:  2042-650X     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101549033     Medline TA:  Food Funct     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. P.O. Box 19945-546. Nabavi208@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protective effect of oral Lactobacilli in pathogenesis of chronic periodontitis.
Next Document:  Genomics of gene banks: A case study in rice.