| Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood flow and impairment of memory in mice. | |
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MedLine Citation:
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PMID: 20096732 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study is to investigate the effect of quercetin, a naturally occurring flavonoid, on cerebral blood flow (CBF), brain energy metabolism, memory impairment, oxidative stress and cholinergic dysfunction in brain following intracerebral (i.c.) streptozotocin (STZ) administration in mice. STZ (0.5mg/kg, i.c.) was administered twice at an interval of 48h. We found a significant reduction in CBF as measured by Laser Doppler Flowmetry (LDF). The brain energy metabolism was also altered as evidenced by significant reduction in brain ATP content. Daily treatment with quercetin (2.5, 5 and 10mg/kg, p.o.) starting from the first dose of STZ showed a dose-dependent restoration of CBF and ATP content. Further, quercetin prevented STZ induced memory impairment as assessed by Morris water maze and passive avoidance tests. Biochemical analysis revealed that STZ significantly increased malondialdehyde (MDA), nitrite and depleted glutathione (GSH) levels in the mice brain. Quercetin decreased oxidative and nitrosative stress as evidenced by a significant decrease in MDA, nitrite and increase in GSH levels. Quercetin also attenuated elevated acetylcholinesterase activity in the STZ-treated mice. Neither STZ (i.c.) nor quercetin showed any change in locomotor activity and blood glucose level. The present study demonstrates the beneficial effects of quercetin in improving CBF along with preventing memory impairment, oxidative stress, altered brain energy metabolism and cholinergic dysfunction caused by STZ in mice. Therefore, consumption of dietary stuff rich in quercetin should be encouraged to ward off dementia associated with vascular and neurodegenerative disorders. |
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Authors:
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Santoshkumar Tota; Himani Awasthi; Pradeep Kumar Kamat; Chandishwar Nath; Kashif Hanif |
Publication Detail:
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Type: Journal Article Date: 2010-01-22 |
Journal Detail:
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Title: Behavioural brain research Volume: 209 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-03-03 Completed Date: 2010-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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Division of Pharmacology, Central Drug Research Institute, CSIR, Chattar Manzil, Lucknow, U.P., India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholinesterase
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metabolism Adenosine Triphosphate / metabolism Animals Antibiotics, Antineoplastic / adverse effects, pharmacology* Antioxidants / pharmacology* Avoidance Learning / drug effects Blood Glucose / drug effects Cerebrovascular Circulation / drug effects* Dose-Response Relationship, Drug Glutathione / metabolism Injections, Intraventricular Laser-Doppler Flowmetry / methods Male Malondialdehyde / metabolism Maze Learning / drug effects Memory Disorders / chemically induced* Mice Motor Activity / drug effects Nitrites / metabolism Quercetin / pharmacology* Statistics, Nonparametric Streptozocin / adverse effects, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antioxidants; 0/Blood Glucose; 0/Nitrites; 117-39-5/Quercetin; 18883-66-4/Streptozocin; 542-78-9/Malondialdehyde; 56-65-5/Adenosine Triphosphate; 70-18-8/Glutathione; EC 3.1.1.7/Acetylcholinesterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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