| Protective effect of probucol on liver injury induced by carbon tetrachloride in rats. | |
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MedLine Citation:
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PMID: 21484128 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To explore protective effect of probucol on liver injury induced by carbon tetrachloride (CCl(4)) in rats. METHODS: We used CCl(4) to induce a rat model of liver injury. Some of those rats were treated with an oral administration of probucol. Liver function, blood lipid, liver tissue malondialdehyde (MDA), superoxide dismutase (SOD), and degree of liver fibrosis were analyzed. RESULTS: Probucol significantly decreased the elevation of serum aspartate transaminase, total bile acid, alkaline phosphatase and cholesterol, and improved liver histopathological changes (including fatty infiltration, inflammation cell infiltration, and fibrosis), decreased liver tissue MDA level, and increased liver tissue SOD level in liver injury rats. CONCLUSIONS: For the first time, we demonstrated that probucol has protective effect against liver injury in animal experiment. The antioxidant action of probucol may play an important role in its hepatoprotective mechanism. Probucol also can reduce serum cholesterol. Thus, probucol may have the potential use in clinical liver diseases in which oxidative stress may be present, especially for the patients with hypercholesterolemia. |
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Authors:
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Yu-Tao Zhan; Jing Weng; Li Li; Qing Xu; Xin Song; Xiao-Xia Guo |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-10 |
Journal Detail:
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Title: Hepatology international Volume: - ISSN: 1936-0541 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-4-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101304009 Medline TA: Hepatol Int Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Gastroenterology and Hepatology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, People's Republic of China, yutaozhan@263.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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