Document Detail

Protective effect of pretreatment with low-dose lipopolysaccharide on D-galactosamine-induced acute liver failure.
MedLine Citation:
PMID:  12014428     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: The effect of low-dose lipopolysaccharide (LPS) induced nitric oxide (NO) on liver damage and survival in rats with acute liver failure caused by a lethal dose of D-galactosamine (D-gal) was studied. RESULTS: Ninety percent of control animals died within 4 days after D-gal injection, but pretreatment with low-dose LPS significantly decreased mortality to 5%. There was marked elevation in serum aspartate aminotransferase and alanine aminotransferase levels 24 h after D-gal injection. These aminotransferases were significantly improved in low-dose LPS pretreated rats 24 h after the administration of D-gal. NG-Nitro-L-arginine-methyl ester, but not NG-nitro-D-arginine-methyl ester, reversed this cytoprotection. CONCLUSION: Pretreatment with low-dose LPS prevents experimental liver failure induced by D-gal through activation of endogenous NO synthesis.
Toru Kono; Hiromi Kotani; Toshiyuki Asama; Noriaki Mamiya; Kei Ohara; Masashi Yoneda; Jun Iwamoto; Shinichi Kasai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of colorectal disease     Volume:  17     ISSN:  0179-1958     ISO Abbreviation:  Int J Colorectal Dis     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-05-16     Completed Date:  2002-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8607899     Medline TA:  Int J Colorectal Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Second Department of Surgery, Asahikawa Medical College, Hokkaido, Japan.
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Enzyme Inhibitors / pharmacology
Lipopolysaccharides / administration & dosage*
Liver / drug effects,  metabolism
Liver Failure, Acute / chemically induced,  drug therapy*,  mortality,  physiopathology
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors
Rats, Inbred F344
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Lipopolysaccharides; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 7535-00-4/Galactosamine; EC Oxide Synthase; EC Aminotransferases; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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