Document Detail


Protective effect of pregnancy for development of uterine leiomyoma.
MedLine Citation:
PMID:  11751438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many factors that can modulate the risk of developing uterine leiomyoma have been identified, including parity. Epidemiological data on decreased risk of developing this disease has been subject to different interpretations regarding whether pregnancy per se is protective or, as leiomyomas are a major cause of infertility, women that develop these tumors are less fertile and thus have lower pregnancy rates. We have utilized an animal model genetically predisposed to uterine leiomyoma to investigate the potential protective effect of pregnancy on the risk of developing this disease. Female Eker rats that carry a mutation in the tuberous sclerosis 2 (Tsc-2) tumor suppressor gene develop uterine leiomyoma with a frequency of 65% when nulliparous. These animals were bred with intact or vasectomized males and tumor incidence determined after a single pregnancy (to confirm fertility) or multiple pregnancies over the lifetime of the animals. Females with multiple litters displayed a dramatic shift in tumor incidence and presentation. Tumor incidence decreased from 71% in single litter females to 10% in females that had multiple litters (average: five litters/animal). Interestingly, females bred with vasectomized males also exhibited a reduced tumor incidence of 41%, suggesting that the hormonal changes associated with early stages of pregnancy that occur in pseudopregnant females may have contributed to the protective effect of pregnancy.
Authors:
C L Walker; K Cesen-Cummings; C Houle; D Baird; J C Barrett; B Davis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Carcinogenesis     Volume:  22     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-12-25     Completed Date:  2002-02-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  England    
Other Details:
Languages:  eng     Pagination:  2049-52     Citation Subset:  IM    
Affiliation:
UT MD Anderson Cancer Center, Science Park Research Division, Park Road 1C, Smithville, TX 78957, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Disease Susceptibility*
Female
Fertility / genetics
Genetic Predisposition to Disease
Incidence
Leiomyoma / genetics,  pathology,  prevention & control*
Male
Mutation
Parity / physiology*
Pregnancy
Pregnancy, Multiple
Pseudopregnancy
Rats
Repressor Proteins / genetics
Risk Factors
Tumor Suppressor Proteins
Uterine Neoplasms / genetics,  pathology,  prevention & control*
Vasectomy
Grant Support
ID/Acronym/Agency:
CA 16672/CA/NCI NIH HHS; ES 07784/ES/NIEHS NIH HHS; ES 08263/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Repressor Proteins; 0/Tumor Suppressor Proteins; 169027-60-5/tuberous sclerosis complex 2 protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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