| Protective effect of the 1742(C/G) polymorphism of human cardiotrophin-1 against left ventricular hypertrophy in essential hypertension. | |
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MedLine Citation:
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PMID: 20683337 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Experimental and clinical evidence supports a role of cardiotrophin-1 (CT-1) in the development of hypertensive left ventricular hypertrophy (LVH). The goal of this study was to investigate the relationship between human CT-1 genetic background and LVH in essential hypertension. METHODS: A total of 900 individuals were genotyped for the 1742(C/G) polymorphism of the human CT-1 gene. Serum CT-1 levels were assessed by ELISA in 681 individuals. Left ventricular parameters were determined by two-dimensional echocardiography in 297 individuals. RESULTS: The prevalence of the GG genotype of the 1742(C/G) polymorphism was reduced in essential hypertension (8.4% in normotensive individuals, 4.9% in hypertensive patients, P = 0.046 versus CC/CG individuals) and in LVH (11.5% in nonhypertrophic normotensive individuals, 12.2% in nonhypertrophic hypertensive patients, 2.6% in hypertensive patients with LVH, P = 0.008 versus CC/CG individuals). Apart from this, GG individuals presented lower serum concentration of CT-1 (GG, 147.1 ± 10.5 fmol/ml; CC/CG, 187.1 ± 4.8 fmol/ml; P = 0.036) and left ventricular mass index (GG, 91 ± 6 g/m; CC/CG, 119 ± 3 g/m; P = 0.002). Multivariate analyses showed that the 1742(C/G) polymorphism was a significant determinant of both left ventricular mass index and serum CT-1, after adjusting for confounding factors. Finally, in-vitro studies supported the functionality of the 1742(C/G) polymorphism. CONCLUSION: Our results indicate that the 1742(C/G) polymorphism of the human CT-1 gene is associated with LVH in hypertension and that the GG genotype may have a protective role. It is suggested that CT-1 is one of the mediators of this association. |
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Authors:
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Pablo A Robador; María U Moreno; Oscar Beloqui; Nerea Varo; Josep Redón; Ana Fortuño; Guillermo Zalba; Javier Díez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-15 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 2219-26 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Sciences, Center for Applied Medical Research, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Blood Pressure Cytokines / genetics* Echocardiography / methods Enzyme-Linked Immunosorbent Assay / methods Female Genetic Predisposition to Disease Genetic Variation Genotype Humans Hypertension / complications, genetics* Hypertrophy, Left Ventricular / complications, genetics* Male Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/cardiotrophin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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