Document Detail


Protective effect of plant sterols against chemically induced colon tumors in rats.
MedLine Citation:
PMID:  7356523     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diets rich in vegetables are associated with a low incidence of colon cancer. Since plant sterols are plentiful in vegetarian diets, we studied the effect of beta-sitosterol on colon tumor formation in rats treated with the carcinogen N-methyl-N-nitrosourea. We demonstrated that beta-sitosterol nullified in part the effect of this direct-acting carcinogen on the colon. We suggest that plant sterols may have a protective dietary action action to retard colon tumor formation. The beneficial effects of vegetarian diets may be enhanced because of the presence of these compounds.
Authors:
R F Raicht; B I Cohen; E P Fazzini; A N Sarwal; M Takahashi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer research     Volume:  40     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / analysis
Cholesterol / analysis
Colonic Neoplasms / analysis,  chemically induced,  prevention & control*
Diet
Diet, Vegetarian
Feces / analysis
Humans
Male
Methylnitrosourea / antagonists & inhibitors*
Neoplasms, Experimental / prevention & control
Nitrosourea Compounds / antagonists & inhibitors*
Rats
Sitosterols / pharmacology*
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Nitrosourea Compounds; 0/Sitosterols; 57-88-5/Cholesterol; 684-93-5/Methylnitrosourea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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