Document Detail

Protective effect of parenteral glutamine supplementation on hepatic function in very low birth weight infants.
MedLine Citation:
PMID:  20416995     Owner:  NLM     Status:  MEDLINE    
BACKGROUND & AIMS: Hepatic dysfunction is one of the most frequent complications of parenteral nutrition. Very low birth weight (VLBW) infants are more sensitive to liver injury due to physiological immaturity. Our studies in animals showed that glutamine supplementation could attenuate TPN-associated liver injury. The aim of study was to investigate whether parenteral glutamine supplementation can improve hepatic tolerance in VLBW infants. METHODS: We performed a double-blind, randomized, and controlled clinical study to investigate whether parenteral glutamine supplementation can improve hepatic tolerance in VLBW infants. Thirty VLBW infants at two children's centers were randomly assigned to either a control group or a glutamine-supplemented group. The primary endpoints were hepatic function and mortality. The secondary endpoints were the time to achieve full enteral nutrition, episodes of gastric residuals, duration of parenteral nutrition, weight and head circumference gain, length of hospitalization, and days on ventilator. RESULTS: The serum levels of aspartate aminotransferase (AST) and total bilirubin (Tbi) were decreased after PN in the glutamine-supplemented group (P < 0.05). No deaths occurred in this study. Four infants assigned to the control group and two infants in the glutamine-supplemented group were withdrawn from the study, according to intention to treat: relative risk [RR]: 1.182; 95% confidence interval [CI]: 0.937-1.490. CONCLUSIONS: Parenteral glutamine supplementation can improve hepatic tolerance in very low birth weight infant, suggesting a hepato-protective effect.
Ying Wang; Ye-Xuan Tao; Wei Cai; Qing-Ya Tang; Yi Feng; Jiang Wu
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2010-04-24
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  29     ISSN:  1532-1983     ISO Abbreviation:  Clin Nutr     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-07     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  307-11     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
Clinical Nutrition Center, Xin Hua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, PR China.
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MeSH Terms
Blood Glucose / analysis
Body Weight
Double-Blind Method
Gastric Emptying
Glutamine / therapeutic use*
Head / growth & development
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight / blood*,  growth & development
Length of Stay
Liver / physiopathology*
Liver Diseases / blood,  mortality,  prevention & control*
Parenteral Nutrition, Total / adverse effects*,  mortality
Protective Agents / therapeutic use*
Respiration, Artificial
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Protective Agents; 56-85-9/Glutamine

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