| Protective effect of pacing on reperfusion-induced ventricular arrhythmias in isolated rat hearts. | |
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MedLine Citation:
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PMID: 7656192 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine whether pacing would have a protective effect similar to preconditioning on reperfusion-induced ventricular arrhythmias and whether this protective effect would be induced by pacing-induced myocardial ischemia. DESIGN: Isolated rat hearts (n = 36) were perfused by the Langendorff technique and the working heart mode. Global ischemia was induced for 10 mins followed by reperfusion for 15 mins. The control group had no pacing, while in the other groups, the hearts were electrically paced three times at 300, 400 and 600 beats/min, respectively, for 5 mins with 1 min intervals between pacings. MAIN RESULTS: The incidence of reperfusion-induced ventricular fibrillation in controls was 100%, whereas that in the 300, 400 and 600 beats/min groups was reduced to 67% (not significant), 50% (P < 0.03) and 30% (P < 0.01), respectively. The mean duration of reperfusion-induced ventricular fibrillation was also significantly reduced in the 300, 400 and 600 beats/min groups compared with the control group. Coronary flow during pacing in the 400 and 600 beats/min groups, but not the 300 beats/min group, was reduced significantly compared with controls. In the 300 beats/min group, oxygen tension of the coronary effluent during pacing was decreased significantly, and proton production and lactate release of coronary effluent during pacing were increased significantly compared with the control group. CONCLUSIONS: Pacing exerted a protective effect similar to preconditioning against reperfusion-induced ventricular arrhythmias. Pacing-induced mild myocardial ischemia, in which coronary flow was maintained, may be involved in the mechanism of this protective effect. |
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Authors:
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S Takeda; T Satoh; M Osada; S Komori; S Mochizuki; K Tamura |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 11 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1995 Jul-Aug |
Date Detail:
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Created Date: 1995-10-03 Completed Date: 1995-10-03 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 573-9 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Yamanashi Medical University, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial* Heart Rate Male Myocardial Ischemia / etiology, physiopathology* Myocardial Reperfusion / adverse effects* Rats Rats, Sprague-Dawley Tachycardia, Ventricular / etiology*, prevention & control Ventricular Fibrillation / etiology*, prevention & control |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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