| Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β(1)-Smads signal pathway. | |
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MedLine Citation:
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PMID: 21409682 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Oxymatrine (1), a component extracted from a traditional Chinese herb Sophora japonica (Sophora flavescens Ait.), has been demonstrated to have a variety of pharmacological actions. Abundant experimental evidence indicates that 1 may exert a protective effect on the cardiovascular system. This study was designed to explore the possible role of 1 against myocardial fibrosis induced by acute myocardial infarction (AMI) and its modulation on transforming growth factor beta 1 (TGF-β(1))-Smads signaling pathways. Rats with AMI induced by ligation of left anterior descending branch were randomly assigned to receive 1 50 and 25 mg/kg intragastrically, and model group which were further compared with sham-operated group, and positive group treated with captopril. The effects of 4-week therapy with 1 starting 24 h after infarction had been investigated based on (1) hemodynamics, (2) tissue weights, (3) biochemical indicator (hydroxyproline contents in left ventricle), and (4) TGF-β(1), TGF-β(1) receptor (TβR(1)), Smad3, Smad4, Smad7, Col1, and Col3 expression by semi-quantitative reverse transcription PCR. Treatment with 1 significantly ameliorated hemodynamics, inhibited the expression of TβR(1) mRNA and Smad3 mRNA, and reduced the left ventricle weight/body weight. The results of this research indicated that 1 might protect against myocardial fibrosis and the mechanism may be involved in modulating TGF-β(1)-Smads signal pathway. |
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Authors:
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Xiang-Chun Shen; Yu-Ping Yang; Ting-Ting Xiao; Jiao Peng; Xing-De Liu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 13 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 215-24 Citation Subset: IM |
Affiliation:
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Research Division of Pharmacology, Guiyang Medical University, Guiyang, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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