| Protective effect of metformin in CD1 mice placed on a high carbohydrate-high fat diet. | |
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MedLine Citation:
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PMID: 20573602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A high carbohydrate-high fat (HC-HF) diet-associated with hyperinsulinemia has been previously reported to induce accelerated growth of prostate cancer in a xenograft model. High energy supply and insulin/insulin growth factor-1 axis are two of the mechanisms proposed. We hypothesize that metformin may have a protective effect against prostate cancer progression by affecting metabolisms associated with high energy intake. In the present study, animals were randomized into five groups, receiving a HC-HF diet with 50, 100, or 250mg/kg body weight (mg/kg) metformin in drinking water, a standard diet or HC-HF diet alone. Animals on the HC-HF diet developed obesity and insulin resistance. They had significantly higher body weight, fasting blood glucose at an upper level of normal range, higher insulin secretion and utilization, and fatty degeneration of the liver. Metformin at the doses employed significantly reduced food and water consumption; however, only a dose of 250mg/kg showed a significant reduction in body weight gain and suppression of gluconeogenesis as well remarkably reduced insulin secretion. There was no observed metformin-related hepato-toxicity in any of the groups. In summary, metformin at various doses exhibits protective effects on the metabolic disorder caused by the HC-HF diet with the most effective protection at a dose of 250mg/kg. These effects may explain its translational role relating to its anti-neoplastic potential. |
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Authors:
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Min Hou; Natalie Venier; Linda Sugar; Mireia Musquera; Michael Pollak; Alex Kiss; Neil Fleshner; Laurence Klotz; Vasundara Venkateswaran |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-02 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 397 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 537-42 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Urology, Sunnybrook Health Science Centre, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet / adverse effects* Dietary Carbohydrates / administration & dosage, adverse effects* Dietary Fats / administration & dosage, adverse effects*, metabolism Gluconeogenesis / drug effects Hypoglycemic Agents / administration & dosage* Insulin / blood, secretion Insulin Resistance Islets of Langerhans / drug effects, secretion Liver / metabolism Male Metformin / administration & dosage* Mice Mice, Inbred Strains Obesity / complications Prostatic Neoplasms / etiology, prevention & control* Weight Gain / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Fats; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 657-24-9/Metformin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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