Document Detail

Protective effect of metallothionein on oxidative stress-induced DNA damage.
MedLine Citation:
PMID:  20380594     Owner:  NLM     Status:  MEDLINE    
Metallothioneins (MTs) are a family of low molecular weight proteins with a high cysteine and metal ion content. They are found in most cells and tissues and can be induced by a number of substances, including various forms of oxidative stress. MTs play a central role in essential trace element homeostasis and in metal detoxification. Because of their peculiar structure, characterized by a large content of thiol groups, MTs also act as a potent antioxidant by protecting against various injuries resulting from reactive oxygen (ROS) or nitrogen species (RNS). In this review, the involvement of MT in the protection of DNA against oxidative stress is discussed.
Natalie Chiaverini; Marc De Ley
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Free radical research     Volume:  44     ISSN:  1029-2470     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  605-13     Citation Subset:  IM    
Laboratory for Biochemistry, Department of Chemistry, Katholieke Universiteit Leuven, BE-3001 Heverlee, Belgium.
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MeSH Terms
Antioxidants / metabolism*
DNA Damage / physiology*
Metallothionein / metabolism*
Oxidative Stress / physiology*
Reactive Oxygen Species / metabolism
Reg. No./Substance:
0/Antioxidants; 0/Reactive Oxygen Species; 9038-94-2/Metallothionein

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