Document Detail


Protective effect of metallothionein against the toxicity of cadmium and other metals(1).
MedLine Citation:
PMID:  11516518     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Metallothionein (MT) is a small-molecular weight, cysteine-rich protein that binds metals. The protective role of MT in Cd toxicity is well established but its ability to protect against toxicity of other metals remains unclear. In this study, wild-type and MT-I and -II null mice (MT-null mice) were used to determine whether MT is protective against the lethality of not only Cd but also Zn, Cu, Fe, Pb, Hg and As. Following daily subcutaneous administration of an increasing dose of each metal, starting with a low, non-toxic dose, we compared the cumulative median lethal dose (LD(50)) of each metal between wild-type and MT-null mice. The LD(50) of Cd for wild-type mice was 6.9-fold higher than for MT-null mice. The LD(50) of Zn was 2.4-fold higher for wild-type mice than for MT-null mice, and 1.4-fold higher for Cu and As. The LD(50) of Hg was 1.3-fold higher for wild-type mice than for MT-null mice, but this was not statistically significant. No difference in LD(50) values was observed between wild-type and MT-null mice following Pb and Fe administration. These results suggest that MT is an important protein in the cellular defense against Cd toxicity and lethality, but it provides much less protection against the lethality of the other metals.
Authors:
J D Park; Y Liu; C D Klaassen
Related Documents :
24139828 - Rapid desensitization of mice with anti-fcγriib/fcγriii mab safely prevents igg-media...
23892988 - Repeated administration of pep-1-cu,zn-superoxide dismutase and pep-1-peroxiredoxin-2 t...
23861788 - Selective modulation of wnt ligands and their receptors in adipose tissue by chronic hy...
23199288 - Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral i...
2401238 - The production of transforming growth factor-beta by chick growth plate chondrocytes in...
11992008 - Enhanced expression of proinflammatory cytokines in the central nervous system is assoc...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology     Volume:  163     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-08-22     Completed Date:  2001-09-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160-7417, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arsenic / toxicity
Cadmium / antagonists & inhibitors,  toxicity*
Cadmium Chloride / administration & dosage,  toxicity
Copper / toxicity
Dose-Response Relationship, Drug
Iron / toxicity
Lead / toxicity
Lethal Dose 50
Mercury / toxicity
Metallothionein / deficiency*
Metals / antagonists & inhibitors,  toxicity*
Mice
Mice, Knockout
Zinc / toxicity
Grant Support
ID/Acronym/Agency:
ES-01142/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Metals; 10108-64-2/Cadmium Chloride; 7439-89-6/Iron; 7439-92-1/Lead; 7439-97-6/Mercury; 7440-38-2/Arsenic; 7440-43-9/Cadmium; 7440-50-8/Copper; 7440-66-6/Zinc; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prophylactic efficacy of amifostine and its analogues against sulphur mustard toxicity.
Next Document:  Comparative uptake behavior of trace elements in adult and suckling rat lens.